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MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
ProteomicsEvaluation of Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics
The Orbitrap Ascend Tribrid mass spectrometer was systematically evaluated in the context of shotgun proteomics, and its performance was compared to that of the previous generation of Tribrid instrument - Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-03-10 | MSV000091467 | MassIVE
TranscriptomicsscRNA-seq of human fetal intestine tissue
Here, we performed single cell RNA sequencing (scRNA-seq) of human fetal duodenal tissue samples from 8 individual biological specimens across 7-21 weeks of gestation. The data set is composed of over 37,000 cells (between 3,000-9,000 cells per time point) from diverse intestinal lineages. Lineages ...
ORGANISM(S): Homo sapiens 
2020-12-12 | E-MTAB-9489 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal duodenal enteroids grown in EGF and/or NRG1
The purpose of this study was to interrogate the role of EGF-family ligands, in particular Epidermal Growth Factor (EGF) and Neuregulin 1 (NRG1), as human intestinal stem cell niche factors. An established duodenal enteroid line derived from a 20.2 week post conception biological specimen was expose...
ORGANISM(S): Homo sapiens 
2020-12-10 | E-MTAB-9720 | biostudies-arrayexpress
ProteomicsEffects of thermal acclimation on the proteome of the planarian Crenobia alpina from an alpine freshwater spring
Is is a fundamental evolutionary question which coordinated molecular changes underly adaptation generally and thermal adaptation specifically. Here we profiled the proteome of the Planarian glacial relict species Crenobia alpina. We sampled individuals from an alpine spring, acclimated groups of in...
ORGANISM(S): Crenobia alpina 
2022-07-28 | PXD024592 | Pride
Lc-ms/ms Planarian Adaptation Climate change Crenobia alpina Acclimation Temperature Freshwater springs 
MetabolomicsProteomic and metabolomic profiling of acute and chronic stress events associated with military exercises.
By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an effort to facil...
2023-12-05 | MTBLS5463 | MetaboLights
TranscriptomicsscRNA-seq of pluripotent stem cell derived human intestinal organoids
Here, we used single cell RNA-sequencing (scRNA-seq) to profile pluripotent stem cell derived human intestinal organoids (HIOs) grown in matrigel or a non-adhesive alginate hydrogel after 28 days of in vitro growth. Additionally, we used scRNA-seq to profile HIOs derived in the presence of Neureguli...
ORGANISM(S): Homo sapiens 
2021-05-21 | E-MTAB-10268 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of pluripotent stem cell derived human intestinal organoids, adult intestine, and human fetal endoderm derived organs
Here, we used single cell RNA-sequencing (scRNA-seq) to profile pluripotent stem cell derived human definitive endoderm and intestinal organoids (HIOs) at several timepoints of in vitro growth (7, 14, and 28 days) and after in vivo growth beneath the kidney capsule of a murine host (4 and 8 wks post...
ORGANISM(S): Homo sapiens 
2021-05-21 | E-MTAB-10187 | biostudies-arrayexpress
MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
TranscriptomicsscRNA-seq of human fetal intestinal ileum tissue
Here, we performed single cell RNA sequencing (scRNA-seq) of human fetal ileum tissue samples from 3 individual biological specimens ages 11.4, 14.4, and 18.9 weeks post conception. The data set is composed of over 16,000 cells from diverse intestinal lineages.
ORGANISM(S): Homo sapiens 
2021-02-22 | E-MTAB-9906 | biostudies-arrayexpress
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