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TranscriptomicsThe head-regeneration transcriptome of the planarian Schmidtea mediterranea
The head-regeneration transcriptome of the planarian Schmidtea mediterranea
ORGANISM(S): Schmidtea mediterranea 
2011-07-15 | E-MTAB-607 | biostudies-arrayexpress
Transcriptomics454 Life Sciences/Roche and Illumina sequencing of small RNAs from planarian samples
Freshwater planarian flatworms possess uncanny regenerative capacities mediated by abundant and collectively totipotent adult stem cells. Key functions of these cells during regeneration and tissue homeostasis have been shown to depend on PIWI, a molecule required for piRNA expression in planarians....
ORGANISM(S): Schmidtea mediterranea 
2009-06-30 | E-GEOD-16159 | biostudies-arrayexpress
TranscriptomicsSingle-cell analysis reveals prominent classes within the planarian stem cell compartment
Single cell qPCR analysis identified two prominent expression signatures within the planarian stem cells, the neoblasts. RNAi against zinc finger protein zfp-1 results in elimination of one of the two classes. Worms were treated with RNAi by feeding. X1 or X2 cells were isolated by FACS, or blastema...
ORGANISM(S): Schmidtea mediterranea 
2014-09-30 | E-GEOD-58057 | biostudies-arrayexpress
ModelsVu2019 - Planarian tissue polarity
The model explores the establishment and stability of the wildtype polarity pattern in planarian flatworms. Initial conditions for A and M fields are chosen as arbitrarily perturbed to demonstrate stability of the wild type pattern. A represents the A/P polarization system, M represents the M/L pola...
2021-10-05 | MODEL2107170001 | BioModels
TranscriptomicsTranscriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea
The transcriptome of the planarian Schmidtea mediterranea is not well characterized. We have used RNA-Seq to characterize the transcriptome in both sexual and asexual strains of S. mediterranea from both untreated and irradiated animals. Moreover, we have performed RNA-Seq on RNA purified from FAC...
ORGANISM(S): Schmidtea mediterranea 
2012-04-24 | E-GEOD-34326 | biostudies-arrayexpress
ModelsVu2019 - Planarian double-head regeneration
This spatio-temporal model explores tissue polarity re-organization during planarian double-head formation upon regeneration with beta-catenin-1 RNAi treatment. Initial conditions for A and M polarity fields are chosen near the wild type pattern and the first 100 time steps are used to establish the...
2021-10-06 | MODEL2110050001 | BioModels
ProteomicsEffects of thermal acclimation on the proteome of the planarian Crenobia alpina from an alpine freshwater spring
Is is a fundamental evolutionary question which coordinated molecular changes underly adaptation generally and thermal adaptation specifically. Here we profiled the proteome of the Planarian glacial relict species Crenobia alpina. We sampled individuals from an alpine spring, acclimated groups of in...
ORGANISM(S): Crenobia alpina 
2022-07-28 | PXD024592 | Pride
Lc-ms/ms Planarian Adaptation Climate change Crenobia alpina Acclimation Temperature Freshwater springs 
TranscriptomicsMolecular markers to characterize the hermaphroditic reproductive system of the planarian Schmidtea mediterranea
Investigation of differences in gene expression between two strains of the planarian Schmidtea mediterranea. The sexual strain are cross-fertilizing hermaphrodites with reproductive organs that develop post-embryonically and the asexual strain reproduces exclusively by transverse fission and fail to...
ORGANISM(S): Schmidtea mediterranea 
2011-11-01 | E-GEOD-32450 | biostudies-arrayexpress
Genomicsneuroendocrine control of planarian regeneration
neuroendocrine control of planarian regeneration
PRJNA867139 | ENA
GenomicsH3K36me3 is significantly more enriched at Set1-affected loci than at MLL1/2-affected loci in planarian stem cells
Histone H3 lysine 4 trimethylation (H3K4me3) is known to correlate with both active and poised genomic loci, yet many questions remain regarding its functional roles in vivo. We identify functional genomic targets of two H3K4 methyltransferases, Set1 and MLL1/2, in both the stem cells (X1) and diffe...
ORGANISM(S): Schmidtea mediterranea 
2015-12-17 | E-GEOD-74419 | biostudies-arrayexpress
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