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GenomicsGLASS-NL DNA-Methylation
Low-grade IDH-mutant glioma are notoriously unpredictable and knowledge on the evolutionary trajectories is limited. The GLASS-NL consortium performed methylome profiling on paired initial and recurrent IDH-mutant astrocytoma tumours to elucidate the temporal changes in DNA-methylation. Whole-exome ...
EGAS00001007546 | EGA
TranscriptomicsDeciphering regulatory mechanisms associated with hemicellulose degradation in Neurospora crassa
Hemicellulose, the second most abundant plant biomass fraction after cellulose, is widely viewed as a potential feedstock for the production of liquid fuels and other value-added materials. Degradation of hemicellulose by filamentous fungi requires production of many different enzymes, which are ind...
ORGANISM(S): Neurospora crassa 
2012-03-26 | E-GEOD-34098 | biostudies-arrayexpress
ProteomicsSingle Cell Proteoform Analysis Using scPiMS
We introduce single-cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells drop casted onto glass slides. Sampling and detection of whole proteoforms by individual ion mass spectrometry enables...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-02 | MSV000093994 | MassIVE
TranscriptomicsConserved and Essential Transcription Factors for Cellulase Gene Expression in Ascomycete Fungi.
Transcriptional profiling with next-generation sequencing methods refined our understanding of the N. crassa transcriptional response to cellulose and demonstrated that the newly characterized transcription factors clr-1 and clr-2 were required for the bulk of that response including induction all m...
ORGANISM(S): Neurospora crassa OR74A 
2012-04-23 | E-GEOD-35227 | biostudies-arrayexpress
TranscriptomicsInduction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins
Transcriptional profiling with next-generation sequencing methods demonstrated that a Neurospora crassa mutant with the three most highly expressed beta-glucosidase genes deleted had a transcriptional response to cellobiose similair to that of wild type N. crassa exposed to cellulose. N. crassa was ...
ORGANISM(S): Neurospora crassa OR74A 
2012-04-04 | E-GEOD-36719 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse hippocampus under ibotenic acid treatment.
Mice (n=85) were anaesthetised by ip injection (0.1 ml/10 g) of xylazine (5%) and ketamine (10%) diluted in sterile water. After placing animals in a stereotactic frame, the skull surface was exposed and holes were drilled at the appropriate sites to allow bilateral infusion of ibotenic acid (10 ï¾µ...
ORGANISM(S): Mus musculus 
2011-03-31 | E-MEXP-2682 | biostudies-arrayexpress
ProteomicsA standardized and reproducible workflow for membrane glass slides in routine histology and spatial proteomics
Defining the molecular phenotype of single cells in-situ is essential for understanding tissue heterogeneity in health and disease. Powerful imaging technologies have recently been joined by spatial omics technologies, promising unparalleled insights into the molecular landscape of biological sample...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040281 | Pride
Antigen retrieval Spatial proteomics Deep visual proteomics Glycerol Membrane slides Histology Proteomics Heat-induced epitope retrieval Laser microdissection 
ProteomicsN-terminal acetylome analyses reveals the substrate specificity profile of Naa50 (Nat5) and implicate NATs in influencing initiator Methionine processing
Co-translational N-terminal (Nt-) acetylation of nascent polypeptides is catalyzed by N-terminal acetyltransferases (NATs). The very N-terminal amino acid sequence is the major factor determining whether or not a given protein is Nt-acetylated. In humans, six different NATs, denoted NatA-NatF, are i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-05-29 | PXD001437 | Pride
N-terminal acetyltransferase / n-terminomics / nt-acetylome / naa50 / nate 
TranscriptomicsA comparative systems analysis of polysaccharide-elicited responses in Neurospora crassa reveals carbon source-specific cellular adaptations
Filamentous fungi are powerful producers of hydrolytic enzymes for the deconstruction of plant cell wall polysaccharides. However, the central question of how these sugars are perceived in the context of the complex cell wall matrix remains largely elusive. To address this question in a systematic f...
ORGANISM(S): Neurospora crassa OR74A 
2013-11-27 | E-GEOD-42692 | biostudies-arrayexpress
UnknownPerformance of residents using digital images versus glass slides on certification examination in anatomical pathology: a mixed methods pilot study.
Not available
S-EPMC4866926 | biostudies-literature
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