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UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
TranscriptomicsPten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify...
ORGANISM(S): Mus musculus 
2012-02-28 | E-GEOD-34839 | biostudies-arrayexpress
TranscriptomicsThe histone demethylase JMJD1A is essential to prostate cancer cells through regulation of c-Myc expression
Analysis of gene expresssion altered upon knockdown of histone demethylase JMJD1A in human prostate cancer cells. The objective is to elucidate the transcriptional programs that are controlled by JMJD1A in human prostate cancer. CWR22Rv1 prostate cancer cells were transduced with lentiviral particle...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-70498 | biostudies-arrayexpress
ProteomicsChaperone-mediated autophagy promotes PCa survival during ARPI through selective proteome remodeling
Defining acute stress response mechanisms that mediate prostate cancer (PCa) treatment resistance will help improve therapeutic outcomes of patients treated with androgen receptor pathway inhibition (ARPI). ARPI causes abrupt environmental changes, subjecting PCa cells to acute metabolic stress. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-26 | PXD036227 | Pride
Prostate Cma Enzalutamide 
UnknownDietary Patterns and Risk of Gleason Grade Progression among Men on Active Surveillance for Prostate Cancer: Results from the Canary Prostate Active Surveillance Study.
Not available
S-EPMC9974882 | biostudies-literature
TranscriptomicsIGR_CAP1_DOCETAXEL_GE_STUDY_AC
'Prostate cancer is the second cancer diagnosed among men worldwide. Beside approval of new therapies in the last five years, chemotherapeutic agents, docetaxel and cabazitaxel taxanes remain key treatments for metastatic castration resistant prostate cancers. However, primary and acquired resistanc...
ORGANISM(S): Homo sapiens 
2018-11-07 | E-MTAB-4869 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity cancer.
The androgen receptor (AR) plays a central role in the development of castration resistant prostate cancer (CRPC). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination dependent degradation, thereby promoting the ...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44319 | biostudies-arrayexpress
UnknownEvaluating the Outcomes of Active Surveillance in Grade Group 2 Prostate Cancer: Prospective Results from the Canary PASS Cohort.
Not available
S-EPMC8917057 | biostudies-literature
UnknownDeveloping a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum.
Not available
S-EPMC7351323 | biostudies-literature
UnknownTreatment in the absence of disease reclassification among men on active surveillance for prostate cancer.
Not available
S-EPMC8738121 | biostudies-literature
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