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TranscriptomicsAntitumor Activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse
(R,R’)-4-methoxy-1-naphthylfenoterol (MNF) inhibits in vitro proliferation of several types of cancer cell lines. In this study, the in vivo antitumor effects of MNF were evaluated using rat C6 glioma cells implanted subcutaneously into the lower flank of 5 week-old NMRI/Nude female Swiss mice. Thre...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-45307 | biostudies-arrayexpress
ProteomicsProfiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.
We have grown C6 glioma cells and rat astrocytes, as well as astrocyte cells co-cultured together with C6 glioma. We performed proteome-wide LC-MS analysis of this experimental groups. The data including LC-MS/MS raw files and exported MaxQuant report. For our co-cultivated in vitro model we used as...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-10-05 | PXD026776 | Pride
Glioma c6 Co-culture Proteome Lc-ms/ms 
GenomicsGenome wide map of H3K4me3 histone modification in C6 rat glioma cells [SOLiD]
We report a map of H3K4me3 - an activiting expression histone modification in C6 rat glioma cells. The data was obtained using whole genome high throughput technology. The sequencing was performed on Solid 5500xl platform. Examination of H3K4me3 histone modification in C6 rat glioma cell line
ORGANISM(S): Rattus norvegicus 
2015-05-07 | E-GEOD-46822 | biostudies-arrayexpress
GenomicsGenome wide maps of H3K4me3 and H3ac histone modifications in C6 rat glioma cells [Illumina]
We report maps of H3K4me3 and H3ac - activiting expression histone modifications in C6 rat glioma cells. The data was obtained using whole genome high throughput technology. The sequencing was performed on HiSeq Ilumina platform. Examination of H3K4me3 histone modification and H3ac histone modific...
ORGANISM(S): Rattus norvegicus 
2015-05-07 | E-GEOD-46820 | biostudies-arrayexpress
TranscriptomicsGenome wide map of Stat3 binding sites in C6 rat glioma cells [NimbleGen]
We report a map of Stat3 binding sites in C6 rat glioma cells. The data was obtained using whole genome technology using NimbleGen microarrays. Examination of Stat3 binding sites in C6 rat glioma cell line
ORGANISM(S): Rattus norvegicus 
2015-05-07 | E-GEOD-47020 | biostudies-arrayexpress
TranscriptomicsTime-series transcription profiling by array of rat microglia treated with C6 glioma-conditioned medium.
Several independent microglia preparations performed on different days were plated onto wells of 24-well plates, and either left untreated (control), treated with the C6 glioma-conditioned medium (GCM). RNA samples were prepared at 6, 24 and 48 hours from the start of the treatment, as well as from ...
ORGANISM(S): Rattus norvegicus 
2018-10-03 | E-MTAB-6143 | biostudies-arrayexpress
TranscriptomicsSelf-maintenance of rat C6 glioma stem cells (GSCs) by their non-GSC progenies
Analysis of Hoechst 33342 dye-effluxing side population cells (SP cells defined as glioma stem cells, GSCs) and dye-retaining main population cells (MP cells defined as non-GSCs) that were FACS-sorted from the C6 glioma cell line stably expressing EGFP (C6-eGFP). ECM-related genes, such as Col4a1 an...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-GEOD-72431 | biostudies-arrayexpress
TranscriptomicsMicroglia treatment with C6 glioma-conditioned medium or with LPS
Several independent microglia preparations performed on different days were plated onto wells of 24-well plates, and either left untreated (control), treated with the C6 glioma-conditioned medium, or treated with LPS.
For each culture condition, a number of RNA samples were prepared, with each sa...
ORGANISM(S): Rattus norvegicus 
2012-12-14 | E-MEXP-2466 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiling of microglia from control and C6 glioma tumor-bearing brain hemisphere in the rat.
The aim of the experiment was to identify differences in gene expression in the microglia due to the presence of a brain tumor, at 14 days after a stereotactic injection of 5 x 10E4 rat C6 glioma cells into the right striatum of the rat. The control (naive) animals were left untreated. The brain hem...
ORGANISM(S): Rattus norvegicus 
2018-01-22 | E-MTAB-5050 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiling of the whole brain hemisphere in the rats with C6-glioma tumor.
The aim of the experiment was to identify differences in gene expression in the whole brain hemisphere due to the presence of a brain tumor. At 21 days after a stereotactic injection of 5 x 10E4 rat C6 glioma cells into the right striatum of the rat the animals were sacrificed and the tumor-bearing...
ORGANISM(S): Rattus norvegicus 
2017-08-31 | E-MTAB-5049 | biostudies-arrayexpress
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