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MetabolomicsMetabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture

Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vascularization and growth. However, despite known metabolic alterations in breast cancer, it remains unclear how lymphatic endothelial cell metabolis...

2024-06-25 | MTBLS859 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsInvestigating the Impact of Acinetobacter lwoffii-ECT1/E6E7 Co-culture Metabolites on Cervical Cell Proliferation and Apoptosis via Untargeted Metabolomics.

This study employed untargeted metabolomics detection combined with bioinformatics analysis to investigate the metabolites from the co-culture of Acinetobacter lwoffiiand cervical precancerous cells ECT1/E6E7. A. lwoffiiwas co-cultured with ECT1/E6E7 cells at an MOI of 100. The culture supernatan...

2025-12-17 | MTBLS13526 | MetaboLights
Metabolomics2E,4E-decadienoic acid, a novel anti-oomycete agent from co-culture of Bacillus subtilis and Trichoderma asperellum

Phytophthora nicotianae is an oomycete pathogen of global significance threatening many important crops. It is mainly controlled by chemosynthetic fungicides, which endangers ecosystem and human health; thus, there is an urgent need to explore alternatives for these fungicides. In this s...

2022-08-01 | MTBLS5405 | MetaboLights
MetabolomicsMetabolomic analysis of extracellular metabolites from bacterial strains SL8, SL12 and their co-culture under cadmium stress

In this study, bacterial strains 'SL8', 'SL12', and the cocultured 'SL8+SL12' were cultivated in LB medium with or without 100 mg/L cadmium(II) for 48 hours (six replicates per treatment). After centrifugation, extracellular metabolites in the supernatant were extracted using a methanol acetonitr...

2026-05-26 | MTBLS14477 | MetaboLights
MetabolomicsMetabolic changes of culture supernatants of Fusobacterium nucleatum co-cultured with other oral microbes (part-II)
Not available
ORGANISM(S): Fusobacterium nucleatum 
ST001261 | MetabolomicsWorkbench
TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
TranscriptomicsmRNASeq of Nitrosomonas europaea and Nitrobacter winogradskyi
N.europaea and N. winogradskyi were grown singly and in co-culture in chemostat to probe for transcriptome diffrences between the two growth conditions. The comparison was done in chemostats. Single cultures maintained with 60 mM ammonium or nitrate, as appropiate, were compared to co-culture maint...
ORGANISM(S): Nitrosomonas europaea 
2014-12-03 | E-GEOD-58052 | biostudies-arrayexpress
TranscriptomicsGene expression profile of cancer cells growing as a co-culture with carcinoma-associated fibroblasts (CAF)
Molecular mechanisms of the cancer cells-carcinoma associated fibroblasts (CAF) interactions growing in vitro conditions as a co-culture. The five canine mammary cancer cell lines were cultured with CAF (isolated from canine mammary cancer) for 72hrs. Then, the cancer cells and CAFs were sorted and ...
ORGANISM(S): Canis lupus familiaris 
2012-05-30 | E-GEOD-29601 | biostudies-arrayexpress
MetabolomicsMass Spectrometry Imaging of Lipids in a Gut Epithelial Cell Model

Scope: The Caco2/HT29-MTX co-culture system is widely used as a cell model of the intestinal epithelium. Although the gut epithelium plays an important role in the uptake of free fatty acids and the resynthesis of triglycerides, the lipid distribution profile of the two-dimensional co-culture sys...

2025-06-14 | MTBLS12599 | MetaboLights
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