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MetabolomicsMetabolic Response of a Chemolithoautotrophic Archaeon to Carbon Limitation

The ubiquitously distributed ammonia-oxidizing archaea generate energy from ammonia and build cell mass from inorganic carbon sources, thereby contributing to both the global nitrogen and carbon cycles. However, little is known about the regulation of their predicted core carbon metabolism. A the...

2025-09-27 | MTBLS11689 | MetaboLights
MetabolomicsStable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation
Untargeted approaches and thus biological interpretation of metabolomics results are still hampered by the reliable assignment of the global metabolome as well as classification and (putative) identification of metabolites. In this work we present an liquid chromatography-mass spectrometry (LC-MS)-b...
2020-02-09 | MTBLS1217 | MetaboLights
MetabolomicsInorganic Carbon Limitation in Cells of the Wild Type and Photorespiratory Mutants of the Cyanobacterium Synechocystis sp. Strain PCC 6803
The amount of inorganic carbon represents one of the main environmental factors determining productivity of photoautotrophic organisms. Using the model cyanobacterium Synechocystis sp. PCC 6803, we performed a first metabolome study with cyanobacterial cells shifted from high CO2 (5% in air) into co...
2015-09-14 | MTBLS5 | MetaboLights
MetabolomicsAtlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Folates participate in the one-carbon metabolism (OCM) cycle, supporting many biochemical pathways. Existing methods to profile folate are limited in the diversity of vitamers they measure and the samples they profile. We present a metabolomics workflow for stable extraction, separation, and meas...

2026-02-10 | MTBLS13484 | MetaboLights
MetabolomicsReprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing

Starch is a primary food ingredient and bulk industrial feedstock. Producing starch through fermentation-based low-carbon microbial manufacturing serves as an arable land-independent and carbon-neutral/negative approach, while the efficiency of this route is highly d...

2025-03-03 | MTBLS12252 | MetaboLights
MetabolomicsOmics-guided global rewiring of yeast metabolism enables high-level production of β-lactoglobulin
This project contains untargeted metabolomic data generated to investigate the metabolic responses of Komagataella phaffii during methanol-free recombinant beta-lactoglobulin production. The study included the bovine beta-lactoglobulin-producing strain B08 and the feline beta-lactoglobulin-producing...
2026-06-05 | MTBLS14680 | MetaboLights
ProteomicsProteome-wide quantitative multiplexed profiling of protein expression: Carbon source dependency in S. cerevisiae
The global proteomic alterations in the budding yeast Saccharomyces cerevisiae due to differences in carbon sources can be comprehensively examined using mass spectrometry-based multiplexing strategies. Here we investigate changes in the S. cerevisiae proteome resulting from cultures grown in minima...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2020-01-30 | MSV000084868 | MassIVE
MetabolomicsImpact of shear stress and moderate electric field on the global metabolic profile of a blended fruit and vegetable juice
This study investigated the impact of moderate electric field (MEF) and shear stress (SS) on the chemical profile of a blended fruit and vegetable juice using untargeted metabolomics. Samples underwent mild thermal treatment, MEF, and a combination of MEF and SS, with subsequent chemical changes ana...
2025-09-30 | MTBLS11719 | MetaboLights
TranscriptomicsTranscriptomic analysis of cultured lung epithelial cells exposed to multiwalled carbon nanotubes (Mitsui7)
There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary respon...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-46999 | biostudies-arrayexpress
TranscriptomicsWhole Blood long non-coding RNA and mRNA Expression Profiles in Humans Exposed to Multi-walled Carbon Nanotubes
As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could p...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-73830 | biostudies-arrayexpress
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