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MetabolomicsFaecal 1H NMR spectroscopy data from medically healthy dogs and dogs suffering from cutaneous renal glomerular vasculopathy (CRGV)

Canine Cutaneous and Renal Glomerular Vasculopathy (CRGV) is a fatal idiopathic disease that has resulted in the death of ~ 330 dogs in the UK since 2012. The disease is characterised by cutaneous lesions/ulcerations on the distal extremities, vasculitis of the glomerular arteries and acute kidne...

2026-01-20 | MTBLS13736 | MetaboLights
TranscriptomicsGlomerular transcriptome from subjects in the NEPTUNE cohort
Glomerular Transcriptome from subjects in the NEPTUNE cohort. A number of samples profiled in this analysis were also profiled in Series GSE68127, and Series GSE108113. RNA from the glomerular compartment of was extracted and processed for hybridization on Affymetrix microarrays. Contributor: NEPTU...
ORGANISM(S): Homo sapiens 
2018-05-17 | E-GEOD-104066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Podocytes reveal use of FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10017 | biostudies-arrayexpress
TranscriptomicsComparison of Glomerular Transcriptome Profiles of Adult-Onset Steroid Sensitive Focal Segmental Glomerulosclerosis and Minimal Change Disease
To search for biomarkers to differentiate Adult-Onset Steroid Sensitive focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Compared the profiles of glomerular transcriptomes between patients with FSGS and patients with MCD using microarray analysis. This dataset is part of ...
ORGANISM(S): Homo sapiens 
2017-01-04 | E-GEOD-69814 | biostudies-arrayexpress
TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
TranscriptomicsRNA expression data from glomeruli lacking von Hippel-Lindau protein in podocytes
We and others have previously shown that glomerular endothelial cells and podocytes express hypoxia-inducible transcription factors (HIFs). HIFs bind to hypoxia response elements in target genes, such as vascular endothelial growth factor, which is continually produced by podocytes throughout life....
ORGANISM(S): Mus musculus 
2010-08-03 | E-GEOD-20235 | biostudies-arrayexpress
TranscriptomicsGlomerular Transcriptome from European Renal cDNA Bank subjects and living donors
Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors. Samples included in this analysis have been previously analyzed using older CDF definitions and are included under previous GEO submissions - GSE47183 (chronic kidney disease samples), and GSE32591 (IgA nephropathy sa...
ORGANISM(S): Homo sapiens 
2018-01-24 | E-GEOD-104948 | biostudies-arrayexpress
MetabolomicsA Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease
Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best ...
2019-07-26 | MTBLS798 | MetaboLights
ProteomicsEffect of glomerular disease on the podocyte cell cycle
Proteomic data from three populations of sorted murine podocytes using the FUCCI (fluorescence ubiquitination cell cycle indicator) Cell Cycle Sensor: Wild-Type podocytes at G0 (WT_G0), Alport Syndrome podocytes at G0 (AS_G0), and Alport Syndrome podocytes at G1 (AS_G1). Cell populations were sorted...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-01-15 | MSV000086705 | MassIVE
TranscriptomicsChanges in mouse kidney glomerular gene expression following dendrin knockout
Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. The highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. Dendrin is a poorly characterized cytosolic component of the slit diaphragm in where...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-47606 | biostudies-arrayexpress
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