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TranscriptomicsHes1 and Liver Glucocorticoid Signaling
To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress
GenomicsJAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice.
JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice.
PRJNA1116062 | ENA
ProteomicsAcute deletion of the glucocorticoid receptor in hepatocytes disrupts postprandial lipid metabolism
Hepatic lipid metabolism is highly dynamic, and disruption of several circadian transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the glucocorticoid receptor (GR) as the liver develops. To address the functional role of GR in the adult liver, we used an acu...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-07 | PXD041168 | Pride
Glucocorticoid receptor knockout mice Dia Mouse Lipid metabolism Circadian rhythm Liver Lc-ms/ms 
TranscriptomicsHES1 Is a Master Regulator of Glucocorticoid Receptor-Dependent Gene Expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-52784 | biostudies-arrayexpress
TranscriptomicsGene Regulation by the Human Glucocorticoid Receptor Dimerization Domain Mutant dim4
A mutation in the dimerization domain of the mouse glucocorticoid receptor (GR), dim1, has recently been shown to bind DNA and regulate gene expression. To expand these studies we created a stable osteosarcoma (U-2 OS) cell line expressing four mutations in the dimerization domain of the human GR, ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26857 | biostudies-arrayexpress
GenomicsGlucocorticoid receptor signaling in adipose tissue I
Glucocorticoid receptor signaling in adipose tissue I
PRJNA1009045 | ENA
GenomicsGlucocorticoid receptor signaling in adipose tissue II
Glucocorticoid receptor signaling in adipose tissue II
PRJNA1009047 | ENA
TranscriptomicsHes1 and Glucocorticoid Signaling in Bone Sarcoma Cells
To investigate the role of HES1 during glucocorticoid signaling in bone sarcoma cells (U2OS-GR cells) , we employed whole-genome microarray expressions in mRNA extracted from control U2OS-GR and Hes1-overexpressed U2OS-GR cells. RNA isolated from control U2OS-GR and Hes1-overexpressed U2OS-GR cells...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52727 | biostudies-arrayexpress
UnknownLiver-specific glucocorticoid action in alcoholic liver disease: Study of glucocorticoid receptor knockout and knockin mice.
Not available
S-EPMC11771271 | biostudies-literature
TranscriptomicsGene expression data of untreated and RA-treated wild type and RXRα-deficient mice liver
Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-50028 | biostudies-arrayexpress
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