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ProteomicsCitrullination of glucokinase is linked to autoimmune diabetes
Inflammation, including reactive oxygen species and inflammatory cytokines in tissues amplify various post-translational modifications (PTMs) of self-proteins. A number of PTMs have been identified as autoimmune biomarkers in the initiation and progression of Type 1 diabetes (T1D). In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028825 | Pride
Post-translational modifications Type 1 diabetes Glucokinase 
TranscriptomicsZinc finger nuclease knockouts of human ADP-glucokinase
Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of human ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in tumour cell lines. The hypothesis tested is that ADPGK utilises ADP to phosphorylate glucose under...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-39497 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in glucokinase activator (GKA)-treated pancreatic islets
To identify the target genes of glucokinase activator (GKA) in islet, GKA-induced gene expression in mouse pancreatic islets was measured at 24 hours after treatment of 30 microM GKA or vehicle. GKA-induced gene expression in mouse pancreatic islets was measured at 24 hours after treatment of 30 mic...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-41248 | biostudies-arrayexpress
GenomicsCharacterizing glucokinase variant mechanisms using a multiplexed abundance assay
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
PRJNA941301 | ENA
TranscriptomicsMolecular Profiling of glucokinase-expressing cells from mouse hypothalamus
Analysis of genes from glucokinase-expressing cells following immunoprecipitation of hypothalamic EGFP-tagged L10 ribosomal protein from Glucokinase-cre/Elongation factor 1 alpha 1 - lox stop lox - EGFPL10 mice
ORGANISM(S): Mus musculus 
2013-09-13 | GSE49868 | GEO
GenomicsMultiplexed assessment of human glucokinase variant activity
Multiplexed assessment of human glucokinase variant activity
PRJNA817232 | ENA
GenomicsBeta cell-targeted glucokinase overexpression
Beta cell-targeted glucokinase overexpression
PRJNA413133 | ENA
TranscriptomicsRNAseq data from mouse beta-cells expressing mutant (GCK Y214C) versus wild-type Glucokinase
The goal of this study is to compare the transcriptome of mouse beta-cells expressing mutant constitutively active Glucokinase versus wild-type Glucokinase.
ORGANISM(S): Mus musculus 
2016-10-15 | GSE86949 | GEO
UnknownEvolution of glucose utilization: glucokinase and glucokinase regulator protein.
Not available
S-EPMC3897444 | biostudies-literature
TranscriptomicsMolecular Profiling of glucokinase-expressing cells from mouse hypothalamus
Analysis of genes from glucokinase-expressing cells following immunoprecipitation of hypothalamic EGFP-tagged L10 ribosomal protein from Glucokinase-cre/Elongation factor 1 alpha 1 - lox stop lox - EGFPL10 mice mRNA obtained by immunoprecipitation in adult Gck-cre/EF1A1-LSL-EGFPL10 mice
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-49868 | biostudies-arrayexpress
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