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TranscriptomicsTranscription profiling of rat chondrocytes treated with glucosamine exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta
Glucosamine proved to be a potent, broad-spectrum inhibitor of IL-1beta. Of the 2,813 genes whose transcription was altered by IL-1beta stimulation (p<0.0001), glucosamine significantly blocked the response in 2,055 (~73%). Glucosamine fully protected the chondrocytes from IL-1-induced expression of...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-6119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae wild type and fks1 strains exposed to glucosamine
We did transcription profiling on the effect of glucosamine in Saccharomyces cerevisiae using Research Genetics strains BY4741 (wild type) and 5251 (fks1). Yeast cells exposed to glucosamine in YPD growth medium show a significant increase in chitin content in the lateral cell wall. Likewise, cell w...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-441 | biostudies-arrayexpress
TranscriptomicsExpression array of glucosamine-fed Drosophila heart/nephrocyte complexes
Examined the expression effects of supplementing Drosophila food on heart and nephrocyte complexes 30 female flies fed standard diet supplemented with 0.1 M glucosamine were dissected in cold ADH, and heart/nephrocyte complexes were harvested and analyzed. Animals were pre-fed glucosamine or sucrose...
ORGANISM(S): Drosophila melanogaster 
2015-06-12 | E-GEOD-69815 | biostudies-arrayexpress
TranscriptomicsMicroarray of human lung cancer cell line A549 treated with glucosamine against untreated controls
D-glucosamine inhibits tumor growth in a xenograft mouse model, and previous studies have explored its antiproliferative mechanisms, with recent findings showing that glucosamine reduces ATP levels in cancer cells and inhibits oncogenes like IGF-1R, HIF-1α, and COX-2. However, the detailed mechanism...
ORGANISM(S): Homo sapiens 
2025-03-18 | E-MTAB-14871 | biostudies-arrayexpress
OtherGlobal mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced ER stress.
Data from ProteomeXchange, PXD ID: PXD000380. Experiment: Treatment, file: MS12236QE_rune_henrik_Treatment_c.mzml. Published as part of Mol Cell Proteomics. 2014 Aug 15 . From the Abstract: {{i}} We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to non...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310003280 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
TranscriptomicsEffect of acetate during Escherichia coli switch from N-Acetyl Glucosamine to Malate
This experiment was performed to challenge E. coli response to acetate when switched from N-Acetyl Glucosamine (NAG) to malate as the main substrate. Here, E. coli BW25113 strain was grown in M9 medium complemented with 15 mM NAG, The cells were grown to mid-exponential phase in shake flasks at 37...
ORGANISM(S): Escherichia coli K-12 
2026-05-12 | E-MTAB-16650 | biostudies-arrayexpress
TranscriptomicsMixed Culture Gene Expression of E. coli and Pseudomonas aeruginosa grown on defined media with N-acetyl glucosamine
Transcriptional profiles of Escherichia coli MG1655 in mixed culture with Pseudomonas aeruginosa PAO1 showed a number of E. coli genes to be upregulated including purA-F and other genes associated with purine synthesis. In contrast, genes associated with pyrimidine synthesis were unaffected. Competi...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-11-29 | E-GEOD-26932 | biostudies-arrayexpress
ProteomicsPREDICTIVE MODELING OF THERAPEUTIC RESPONSE TO CHONDROITIN SULFATE/GLUCOSAMINE HYDROCHLORIDE IN KNEE OSTEOARTHRITIS
In the present study we explored potential protein biomarkers useful to predict the therapeutic response of osteoarthritis (OA) patients treated with pharmaceutical grade Chondroitin sulfate/Glucosamine hydrochloride (CS+GH; Droglican, Bioiberica), in order to optimize therapeutic outcomes.
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD012444 | Pride
Predictive biomarkers Chondroitin sulfate/glucosamine hydrochloride Proteomics Osteoarthritis 
TranscriptomicsYeast glucosamine treatment
We did transcription profiling on the effect of glucosamine in Saccharomyces cerevisiae using Research Genetics strains BY4741 (wild type) and 5251 (fks1). Yeast cells exposed to glucosamine in YPD growth medium show a significant increase in chitin content in the lateral cell wall. Likewise, cell w...
ORGANISM(S): Saccharomyces cerevisiae 
2003-05-30 | GSE441 | GEO
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