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TranscriptomicsTranslation profiling of mouse pancreatic beta cells incubated in high or low glucose concentration media to identify proteins regulated by glucose
To identify proteins regulated by glucose through changes in their rate of protein synthesis, translational profiling of MIN6 cells acutely incubated at either low or high glucose concentration was performed (i.e. microarray analysis was performed on mRNAs associated with polysomes, as an increase i...
ORGANISM(S): Mus musculus 
2007-08-01 | E-MEXP-867 | biostudies-arrayexpress
TranscriptomicsGlucose depletion inhibits translation initiation in yeast - polysome and monosome profiling
This is a polysome/monosome profiling study on yeast undergoing glucose depletion. Polysomes and monosomes are extracted and the transcripts bound to each fraction are measured by microarray. The study reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-11 | E-MEXP-3038 | biostudies-arrayexpress
TranscriptomicsTimecourse of total and polysome-associated mRNA levels post glucose deprivation
Cell survival in changing environments requires appropriate regulation of gene expression, including post-transcriptional gene regulatory mechanisms. Based on reporter gene studies in glucose-starved yeast, it was proposed that translationally silenced eukaryotic mRNAs accumulate in P-bodies and can...
ORGANISM(S): Saccharomyces cerevisiae Sigma1278b 
2011-09-04 | E-GEOD-31392 | biostudies-arrayexpress
ProteomicsLC-MS of S. cerevisiae scale-down cultivations
Chemostat cultivation mode imposes selective pressure on cells, which may result slow adaptation in the physiological state over time. We applied a two-compartment scale-down chemostat system simulating glucose gradients to characterize the long-term (100’s of hours) response of S. cerevisiae to flu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-06-09 | PXD015536 | Pride
Scale-down Glucose gradients Fermentation Proteome S. cerevisiae 
TranscriptomicsCO2/HCO3- perturbations of simulated large-scale gradients in a novel scale-down device cause fast transcriptional responses in Corynebacterium glutamicum
The exploration of scale-down models to imitate the influence of large scale bioreactor inhomogeneities on cellular metabolism is a topic with increasing relevance. While gradients of substrates, pH, or dissolved oxygen are often investigated, oscillating CO2/HCO3- levels, a typical scenario in larg...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-05-15 | E-MTAB-2585 | biostudies-arrayexpress
UnknownDynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones.
Not available
S-EPMC6315134 | biostudies-literature
GenomicsSelective Utilisation of Glucose Metabolism Guides Mammalian Gastrulation
Selective Utilisation of Glucose Metabolism Guides Mammalian Gastrulation
PRJNA1134226 | ENA
TranscriptomicsApoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
To explore the molecular pathways underlying thiazolidinediones effects on pancreatic islets in conditions mimicking normo- and hyperglycemia, apoptosis rate and transcriptional response to Pioglitazone at both physiological and supraphysiological glucose concentrations were evaluated. Adult rat isl...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-40119 | biostudies-arrayexpress
TranscriptomicsSelective Utilisation of Glucose Metabolism Guides Mammalian Gastrulation
The prevailing dogma for morphological patterning in developing organisms argues that the combined inputs of transcription factor networks and signalling morphogens generate spatially and temporally distinct expression patterns1. However, recent work spanning multiple disciplines has highlighted the...
ORGANISM(S): Mus musculus 
2024-08-01 | GSE271973 | GEO
UnknownHybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth.
Not available
S-EPMC10705082 | biostudies-literature
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