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MetabolomicsGlycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat Induces Glucose Intolerance Through β-cell Damage
Not available
ORGANISM(S): Mus musculus 
ST002161 | MetabolomicsWorkbench
TranscriptomicsProgressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation
Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolera...
ORGANISM(S): Mus musculus 
2013-12-05 | E-GEOD-52550 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white adipose tissue from Lldlr-/- and Lldlr-/-Mif-/- mice
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs development of insulin resistance, glucose intolerance and associated atherosclerotic disease
ORGANISM(S): Mus musculus 
2009-06-19 | E-TABM-524 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively comp...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11116 | biostudies-arrayexpress
GenomicsIrisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
Irisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
PRJNA1192701 | ENA
GenomicsIrisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
Irisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
PRJNA1191051 | ENA
GenomicsEndothelial TFEB improves glucose intolerance via upregulation of IRS1 and IRS2
Endothelial TFEB improves glucose intolerance via upregulation of IRS1 and IRS2
PRJNA622861 | ENA
TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of either LFD and HFD-treated Alb::GC mice and AP20187-treated TTR::Fv2E-PERK mice
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2alpha (eIF2a)-specific phosphatase, GADD34, was used to selectively ...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11210 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle overexpressing PPARalpha
This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link betw...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5777 | biostudies-arrayexpress
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