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MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
MetabolomicsSystem Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
TranscriptomicsTime series analysis of glucose-lactose diauxie: involvement of stringent response
Guanosine 3 ,5 -bispyrophosphate (ppGpp), also known as ‘‘magic spot,’’ has been shown to bind prokaryotic RNA polymerase to down-regulate ribosome production and increase transcription of amino acid biosynthesis genes during the stringent response to amino acid starvation. Because many environmenta...
ORGANISM(S): Escherichia coli 
2007-03-17 | E-GEOD-7265 | biostudies-arrayexpress
ProteomicsOGDH interactome upon glucose starvation
The adaptation of tumor cells to metabolic stress is crucial for tumor development. We demonstrate that the translation of NRF2, a master regulator of antioxidant response, is controlled by the OGDH-METTL3 axis in melanoma for glucose starvation adaptation. To elucidate the regulatory mechanism of t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD048230 | Pride
Glucose starvation Heat shock protein family a member 9 (hspa9) Α-ketoglutarate dehydrogenase (ogdh) 
ProteomicsIdentification of phosphorylation sites and binding proteins of Saccharomyces cerevisiae Tda1
Tda1 in Saccharomyces cerevisiae is a protein kinase that is activated in response to glucose starvation. However, how it is activated has not been investigated for a long time. In this analysis, yeast cells were grown in high (2%) or low (0.05%) glucose medium, and the lysate were subjected to immu...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2025-03-24 | PXD060707 | JPOST Repository
MetabolomicsA local source of insulin in the eye governed by phagocytosis and starvation
Not available
ORGANISM(S): Mus musculus 
ST001897 | MetabolomicsWorkbench
TranscriptomicsAdaptation of E. histolytica to long term glucose starvation
We have performed a DNA microarray analysis of gene expression in trophozoites which were adapted to grow in a media depleted from glucose for one month and on glucose-starved trophozoites which were recovered with the addition of glucose.
ORGANISM(S): Entamoeba histolytica 
2012-07-01 | E-MTAB-1187 | biostudies-arrayexpress
TranscriptomicsStarvation and chemotherapy
Tumor chemoresistance is often associated to high aerobic glycolysis rates and reduced oxidative phosphorylation by cancer cells, a phenomenon called the “Warburg effect”. Thus, a treatment reversing the Warburg effect could decrease tumor cell survival both in the presence or absence of chemothera...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-60653 | biostudies-arrayexpress
GenomicsRNA changes upon glucose starvation
RNA changes upon glucose starvation
PRJNA1059633 | ENA
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