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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
ProteomicsGlutamate methylation on histones H4 and H2B
Glutamate methylation is a novel histone modification discovered on histones H4 (E52/E53, E63, E74) and histone H2B (E96)
ORGANISM(S): Homo sapiens (Human) Drosophila melanogaster (Fruit fly) Phaeodactylum tricornutum Caenorhabditis elegans Thalassiosira pseudonana 
2025-02-10 | PXD053679 | Pride
Diatoms Transcriptional regulation Glutamate methylation Histones structure Nucleosome stability 
TranscriptomicsA vegan diet epigenetically modulates inflammatory pathways and biological aging: Genome-wide DNA methylation analysis of a one-month isocaloric vegan versus meat-rich dietary intervention
We investigated the impact of a vegan and meat-rich diet on the underlying epigenetic modfications of DNA methylation signatures in the blood of human study participants. Therefore, we analyzed genome-wide DNA methylation from two human cohorts at baseline and following an one-month dietary interven...
ORGANISM(S): Homo sapiens 
2026-07-21 | E-MTAB-17025 | biostudies-arrayexpress
MetabolomicsAn integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients

INTRODUCTION: The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding of molecular features as well as their metabolic pathways...

2021-10-06 | MTBLS869 | MetaboLights
TranscriptomicsDysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets (RNA-Seq)
Backgroud:Epigenetic modifications (especially altered DNA methylation) resulting in altered gene expression may be one reason for development failure or the abnormality of the cloned animals, but the underlying mechanism of the abnormal phenotype in the cloned piglets remains unrevealed. Some clone...
ORGANISM(S): Sus scrofa 
2014-09-03 | E-GEOD-51282 | biostudies-arrayexpress
UnknownIdentification and validation of eukaryotic aspartate and glutamate methylation in proteins.
Not available
S-EPMC2921173 | biostudies-literature
GenomicsDysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets (MeDIP-seq)
Backgroud:Epigenetic modifications (especially altered DNA methylation) resulting in altered gene expression may be one reason for development failure or the abnormality of the cloned animals, but the underlying mechanism of the abnormal phenotype in the cloned piglets remains unrevealed. Some clone...
ORGANISM(S): Sus scrofa 
2014-09-03 | E-GEOD-51476 | biostudies-arrayexpress
UnknownGlutamate Methylation, a Novel Histone Mark in Diatoms: Mass Spectrometry Identification and Structural Characterization.
Not available
S-EPMC12070036 | biostudies-literature
Methylation profilingAlpha-synuclein overexpression is associated with epigenomic dysregulation of glutamate signaling and locomotor pathways
Although Parkinson’s disease (PD) is one of the most rapidly growing neurological disorders, interindividual differences in PD etiology related to genetics are not fully understood. Here, we demonstrate genome-wide DNA methylation and hydroxymethylation alterations associated with overexpression of ...
ORGANISM(S): Homo sapiens 
2021-08-02 | GSE181126 | GEO
TranscriptomicsMethylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs)
Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However,...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41215 | biostudies-arrayexpress
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