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In this study we identified protein-protein crosslinking through lys or protein N-terminus with Gln/Glu residues in aged human lens tissues. Such crosslinks could be reproduced experimentally by incubation of Glu- or Gln-containing peptides and their formation were consistent with an amino group att...
ORGANISM(S): Homo sapiens (Human) 
2023-08-01 | PXD022991 | Pride
Glutarimide analogs, including thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce the ubiquitination and proteasomal degradation of specific zinc finger (ZF) proteins. While the core structural motif recognized by CRBN is characterized, it alone does not account for the full specificit...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD056867 | Pride
Glutarimide analogs, including thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce the ubiquitylation and proteasomal degradation of specific zinc finger (ZF) proteins. While the core structural motif recognized by CRBN is known, it alone does not account for the full specificity of sub...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD056913 | Pride
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