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ProteomicsAssociation of tear fluid glutathione synthetase and glutathione levels with amyloid positivity
Tear fluid is a promising source of biomarkers for Alzheimer’s disease (AD). This study characterized the tear fluid proteome across AD and dementia stages. Tear fluid was collected from 60 participants, cognitively normal (CN) individuals (n=32), patients with mild cognitive impairment (n=14), and ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-25 | PXD072063 | Pride
Tear fluid Amyloid pet Alzheimer’s disease Dementia Glutathione synthetase Diagnosis Proteomics Immunoassay Biomarkers 
MetabolomicsPlasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Not available
ORGANISM(S): Plasmodium falciparum 
ST001660 | MetabolomicsWorkbench
ProteomicsIsotopic-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation
Investigated protein glutathionylation in HL-1 cardiomyocyte cells in response to hydrogen peroxide using a clickable glutathione approach. After exposure, or not, to hydrogen peroxide the glutathionylated proteins with heavy or light azido glutathione were enriched and subjected to LC-MS/MS analysi...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014937 | Pride
Clickable glutathione Glutathionylation Cardiomyocyte 
MetabolomicsMetabolic effect of the loss of mitochondrial-specific aspartyl-tRNA synthetase Das2 on mouse intestinal epithelial cells
Not available
ORGANISM(S): Mus musculus 
ST002184 | MetabolomicsWorkbench
MetabolomicsMultiple modes of interfering with the activity of Plasmodium falciparum cytoplasmic isoleucyl-tRNA synthetase illustrate the enzyme is a promising antimalarial target.
Not available
ORGANISM(S): Plasmodium falciparum 
ST002078 | MetabolomicsWorkbench
ProteomicsClickable Glutathione Approach for Identification of Protein Glutathionylation in Response to Glucose Metabolism
Glucose metabolism and mitochondrial function are closely interconnected with cellular redox-homeostasis. Although glucose starvation, which often occurs in ischemic heart or insufficient vascularization of tumor cells, is known to induce redox-disturbance, global and individual protein glutathionyl...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004026 | Pride
Glutathionylation 
UnknownRice plants have three homologs of glutathione synthetase genes, one of which, OsGS2, codes for hydroxymethyl-glutathione synthetase.
Not available
S-EPMC6508825 | biostudies-literature
TranscriptomicsTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Carbonyl chloride (phosgene) is a toxic industrial compound (TIC) widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 hr), potentially life-threatening pulmonary edema and irreversible acute lu...
ORGANISM(S): Mus musculus 
2007-06-25 | E-GEOD-2565 | biostudies-arrayexpress
TranscriptomicsFunctions and adaptive responses to oxidative stress of the thioredoxin and glutathione pathways in Clostridium acetobutylicum
Oxidative stress is harmful for organism and occurs when the cells exposed to superoxid, hydrogen peroxide and alkylhydroperoxides. In microorganism, the glutathione- and thioredoxin-dependent reduction systems are universal and play an important role in response to defending oxidative stress. The _...
ORGANISM(S): Clostridium acetobutylicum ATCC 824 
2015-04-13 | E-MTAB-2747 | biostudies-arrayexpress
UnknownSite directed mutagenesis of Schizosaccharomyces pombe glutathione synthetase produces an enzyme with homoglutathione synthetase activity.
Not available
S-EPMC3473041 | biostudies-literature
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