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MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9836 | MetaboLights
TranscriptomicsCoordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont
Analysis of B. thetaiotaomicron trans-envelope signaling mutants in ECF-sigma factors, anti-sigma factors and SusC-like transporters. B. thetaiotaomicron mutants were transcriptionally profiled after growth in vitro in either minimal medium plus glucose or minimal medium plus neutral O-glycans
ORGANISM(S): Bacteroides thetaiotaomicron VPI-5482 
2010-05-18 | E-GEOD-14592 | biostudies-arrayexpress
MetabolomicsLignocellulose adaptation drives polysaccharide biosynthesis in Tremella fuciformis: Metabolomic and proteomic insights into CAZyme regulation
The polysaccharide content of T. fuciformis grown on a Cyclobalanopsis substrate (TY3) was significantly higher than those grown on a mixed substrate (TF1) made of wheat bran and cottonseed hull. Metabolomics and proteomics were used to assess the effects of the lignoce...
2025-07-08 | MTBLS12694 | MetaboLights
ProteomicsBlockage of O-linked glycan biosynthesis in Burkholderia is toxic: Tn7_ogcI_validation
Burkholderia species are associated with several life-threatening human infections, often resulting in high morbidity and mortality rates due to their innate resistance to antibiotics. To improve clinical outcomes, new therapies targeting conserved, yet unique, Burkholderia pathways are needed. One ...
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2025-10-22 | PXD055576 | Pride
Glycosylation Burkholderia 
ProteomicsGlycan Markers of Human Stem Cells Assigned with Beam Search Arrays
Glycan antigens recognized by monoclonal antibodies have served as stem cell markers. To understand regulation of their biosynthesis and their roles in stem cell behavior precise assignments are required. We have applied state-of-the-art glycan array technologies to compare the glycans bound by five...
ORGANISM(S): Cellular Organisms 
2019-06-18 | PXD013972 | JPOST Repository
ProteomicsBlockage of O-linked glycan biosynthesis in Burkholderia is toxic: OgcI Complementation
Burkholderia species are associated with several life-threatening human infections, often resulting in high morbidity and mortality rates due to their innate resistance to antibiotics. To improve clinical outcomes, new therapies targeting conserved, yet unique, Burkholderia pathways are needed. One ...
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2025-10-22 | PXD054867 | Pride
Glycosylation Burkholderia 
ProteomicsBlockage of O-linked glycan biosynthesis in Burkholderia is toxic: OgcX complementation
Burkholderia species are associated with several life-threatening human infections, often resulting in high morbidity and mortality rates due to their innate resistance to antibiotics. To improve clinical outcomes, new therapies targeting conserved, yet unique, Burkholderia pathways are needed. One ...
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2025-10-22 | PXD056440 | Pride
Glycosylation Burkholderia 
ProteomicsBlockage of O-linked glycan biosynthesis in Burkholderia is toxic: OgcAB complementation
Burkholderia species are associated with several life-threatening human infections, often resulting in high morbidity and mortality rates due to their innate resistance to antibiotics. To improve clinical outcomes, new therapies targeting conserved, yet unique, Burkholderia pathways are needed. One ...
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2025-10-22 | PXD055163 | Pride
Glycosylation Burkholderia 
ProteomicsBlockage of O-linked glycan biosynthesis in Burkholderia is toxic: OgcA complementation
Burkholderia species are associated with several life-threatening human infections, often resulting in high morbidity and mortality rates due to their innate resistance to antibiotics. To improve clinical outcomes, new therapies targeting conserved, yet unique, Burkholderia pathways are needed. One ...
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2025-10-22 | PXD054956 | Pride
Glycosylation Burkholderia 
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