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MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
MetabolomicsVirus-encoded glycosyltransferases hypermodify DNA with diverse glycans

Enzymatic modification of DNA nucleobases can coordinate gene expression, nuclease protection or mutagenesis. We recently discovered a clade of phage-specific cytosine methyltransferase (MT) and 5-methylpyrimidine dioxygenase (5mYOX) enzymes that produce 5-hydroxymethylcytosine (5hmC) as a precur...

2024-08-22 | MTBLS10724 | MetaboLights
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
ProteomicsIon Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans
The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inherent complexity of glycans and the diversity in the O-core stru...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2024-03-19 | PXD050530 | Pride
O-glycans  ion mobility  mass spectrometry  isomeric separation  dda  proteome 
UnknownSimultaneous quantification of N- and O-glycans using a solid-phase method.
Not available
S-EPMC5877797 | biostudies-literature
UnknownTargeted MultiNotch MS3 Approach for Relative Quantification of N-Glycans Using Multiplexed Carbonyl-Reactive Isobaric Tags.
Not available
S-EPMC5899513 | biostudies-literature
UnknownEndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans.
Not available
S-EPMC4551147 | biostudies-literature
UnknownMicro-competition system for Raman quantification of multiple glycans on intact cell surface.
Not available
S-EPMC5707490 | biostudies-literature
UnknownN-linked glycosite profiling and use of Skyline as a platform for characterization and relative quantification of glycans in differentiating xylem of Populus trichocarpa.
Not available
S-EPMC5209793 | biostudies-literature
ProteomicsLibrary-based virtual match-between-runs quantification scheme enabled by GlyPep-Quant dramatically enhances the identification of site-specific glycans and detection of occupancy ratio changes
Glycosylation changes are closely related to various diseases like cancer. However, the quantitative analysis of the site-specific glycans at proteomics scale remains challenging because of the extremely low interpretation rate of glycopeptide spectra. Here, we present a new software tool, GlyPep-Qu...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Schizosaccharomyces pombe 
2025-07-06 | PXD057799 | Pride
Proteomics  glycosylation  site-specific glycan  quantification  match-between-runs 
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