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MetabolomicsLipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis
Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remai...
2017-08-22 | MTBLS408 | MetaboLights
MetabolomicsParabacteroides distasonis Improving osteoporosis progression through glycerophospholipid metabolism_blood

Backround&Aim: Dysbiosis of gut microbiota is closely related to the pathogenesis of osteoporosis (OP). This study aimed to identify probiotic candidates and gut-derived metabolites capable of ameliorating osteoporosis via modulation of bone metabolism. 

Methods: Ovariect...

2025-08-01 | MTBLS12803 | MetaboLights
MetabolomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
MetabolomicsEarly-life social experiences remodel hippocampal glycerophospholipid metabolism linked to adult memory

Early-life experiences profoundly shape brain development and long-term cognition. Environmental enrichment (EE) and social isolation (SI) represent opposing forms of stimulation and deprivation, yet the metabolic mechanisms connecting these conditions to cognitive outcomes remain poorly defined....

2025-12-04 | MTBLS13454 | MetaboLights
MetabolomicsIntegrated Transcriptomics, Proteomics, and Metabolomics Analysis Reveals Newcastle Disease Virus Reshapes Glycerophospholipid Metabolism

A549 cells were infected with NDV at a multiplicity of infection (MOI) of 3 at 37°C, and the cells were collected 24 hours post-infection.

2025-11-05 | MTBLS13267 | MetaboLights
MetabolomicsMass spectrometry-based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism
Not available
ORGANISM(S): Homo sapiens 
ST001267 | MetabolomicsWorkbench
MetabolomicsMulti-omics reveals the DR5-FXR-CHPT1 axis governs hepatocyte pyroptosis via glycerophospholipid remodeling after major partial hepatectomy
Acute liver injury following major partial hepatectomy (PHx), manifesting as small-for-size syndrome (SFSS) and post-hepatectomy liver failure (PHLF), carries high mortality. However, the key mechanisms underlying irreversible remnant liver injury and cell death remain poorly understood, particularl...
2026-08-16 | MTBLS14980 | MetaboLights
MetabolomicsCPT2 inhibition activates selective autophagy by enhancing glycerophospholipid biosynthesis in colorectal cancer

Metabolic reprogramming is one of the hallmark events in colorectal cancer (CRC).  Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identified abnormal lipid accumulation and significant downregulation of fatty acid metabolism in CRC...

2025-09-01 | MTBLS12783 | MetaboLights
MetabolomicsPuerarin Combined with Hericium Erinaceus Insoluble Dietary Fiber Alleviate Obesity Induced by High-fat Diet Through Regulating the Glycerophospholipid Metabolism Pathway Influenced by Gut Microbiota
The combination of HEIDF and Pue holds significant importance in the context of obesity. This synergistic effect not only aids in weight management but may also enhance metabolic health through various mechanisms, including increased satiety and promotion of fat oxidation. Therefore, incorporating t...
2025-02-17 | MTBLS12195 | MetaboLights
ProteomicsGlycerophospholipid and amino acid metabolism impairment during Congenital Zika Syndrome development
Zika virus (ZIKV) can be transmitted vertically to the fetus, having a high chance to develop Congenital Zika Syndrome (CZS). Studies have shown that ZIKV impairs brain development. However, little is known about the molecular differences between non- microcephalic ZIKV-infected fetuses and microcep...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD039643 | Pride
Metabolomics Congenital zika syndrome Amino acid metabolism Zika virus Glycerophospholipid metabolism Amniotic fluid 
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