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TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-20015 | biostudies-arrayexpress
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
TranscriptomicsTranscription profiling of muscles from mice with genetically modified muscle glycogen content to study the impact of glycogen content on gene expression.
Anterior tibialis removed from 3-month old muscle glycogen synthase WT or knockout mouse. RNA was extracted using GibcoBRL TRIzol Reagent and a Quiagen RNeasy kit. Targets were produced using standard Affymetrix procedures from about 5ug of total RNA. GSM40057-GSM40063 AND GSM40956. Liver removed fr...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2198 | biostudies-arrayexpress
ProteomicsGSK-3 Interactomes from APMS and BioID
Interactomes of GSK-3 Isoforms compared by APMS (in HEK293) and BioID (in HEK293 and HeLa cells).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-15 | MSV000090908 | MassIVE
ModelsKoenig2012 - Hepatic Glucose Metabolism
Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism Kinetic Model of Human Hepatic Glucose Metabolism Authors Matthias Koenig, Sasc...
2005-01-01 | MODEL1204270001 | BioModels
ModelsKoenig2012 - Hepatic Glucose Metabolism
Kinetic Modeling of Human Hepatic Glucose Metabolism in Type 2 Diabetes Mellitus Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy* Kinetic Model of Human Hepatic Glucose Metabolism in T2DM Authors ...
2005-01-01 | MODEL1209260000 | BioModels
ProteomicsJin_Context_dependent_interactions_between_HSP90_and_kinase_clientele
This submission consists of the mass spectrometry raw files for the manuscript by Jin et al. (Mutational analysis of GSK3B protein kinase together with kinome-wide binding and stability studies suggest context-dependent recognition of kinases by the chaperone HSP90). This submission contains files f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-01-06 | MSV000079445 | MassIVE
GenomicsGlycogen synthase kinase-3 is essential for Treg development and homeostasis
Glycogen synthase kinase-3 is essential for Treg development and homeostasis
PRJNA1162894 | ENA
GenomicsGlycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear. Here, we report that at early G1 the glycogen synthase kinase (GSK) 3β ...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-57153 | biostudies-arrayexpress
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