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MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF-and M-CSF-differentiated mouse macrophages

Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions. In vitro macrophage models could be derived from ...

2023-09-19 | MTBLS6502 | MetaboLights
TranscriptomicsTranscription profiling of mouse wild type and Stat5a or 5b knock-out blood cells treated with GM-CSF to induce granulopoiesis
GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administratio...
ORGANISM(S): Mus musculus 
2009-10-10 | E-GEOD-14672 | biostudies-arrayexpress
TranscriptomicsHuman monocyte-derived macrophages polarized by GM-CSF or M-CSF
Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2) Human peripheral blood monocytes from three independent healthy donors (#1, #2 and #3) were isolated by anti-CD14-labeled magnetic microbead...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-27792 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human PMNs to compare global gene expression in human neutrophils during spontaneous apoptosis with that in cells cultured with human GM-CSF
PMNs were isolated from venous blood of healthy individuals in accordance with a protocol approved by the Institutional Review Board for Human Subjects, National Institute of Allergy and Infectious Diseases. Human PMNs (107) were cultured in RPMI/H -/+ 100 ng/ml GM-CSF at 37°C and 5% CO2 for up to ...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-2803 | biostudies-arrayexpress
ProteomicsProteomic analysis of GM-CSF and M-CSF polarized bone marrow derived macrophages
Bone marrow cells were isolated, primed with M-CSF (M-BMDM) or GM-CSF (GM-BMDM) and cultured for 7 days. The proteomic difference between GM-BMDM and M-BMDM were analyzed to describe the phenotye and function of two types of macrophages.
ORGANISM(S): Mus Musculus 
PXD041180 |
TranscriptomicsMicroarray analysis of WT bone marrow myeloid progenitors, BM cultured with GM-CSF and M-CSF, and monocytes treated with GM-CSF
Analysis of genes induced in DC precursors and in BM cells and monocytes treated with GM-CSF For progenitor arrays, bone marrow progenitors (CMP, GMP, CDP, and pre-cDC) were harvested from WT C57Bl/6 mice. For culture arrays, BM was cultured in the presence of GM-CSF or M-CSF and adherent and non-a...
ORGANISM(S): Mus musculus 
2012-05-20 | E-GEOD-37029 | biostudies-arrayexpress
TranscriptomicsGM-CSF induced gene-regulation in human monocytes
Human and murine studies showed that granulocyte macrophage colony-stimulating factor (GM-CSF) exerts beneficial effects in intestinal inflammation. To explore whether GM-CSF mediates its effects via monocytes, we analyzed effects of GM-CSF on monocytes in vitro and assessed the immunomodulatory pot...
ORGANISM(S): Homo sapiens 
2014-11-27 | E-GEOD-63662 | biostudies-arrayexpress
TranscriptomicsAntagonism between glucocorticoid and both GM-CSF and M-CSF
In this study, we compared human monocytes treated with GM-CSF, M-CSF, dexamethosone or in combination with dexamethasone. A comparison of the different monocyte populations was made using microarray profiling.
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-2212 | biostudies-arrayexpress
TranscriptomicsMouse GM-CSF-related alveolar macrophage genome-wide expression data
GM-CSF receptor-β deficient (Csf2rb–/– or KO) mice develop a lung disease identical to hereditary pulmonary alveolar proteinosis (hPAP) in humans with recessive CSF2RA or CSF2RB mutations that impair GM-CSF receptor function. We performed pulmonary macrophage transplantation (PMT) of bone marro...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-60528 | biostudies-arrayexpress
TranscriptomicsInterferon-gamma critically determines dendritic cell function
A growing body of evidence suggests that inflammatory cytokines have a dualistic role in immunity. In this study, we sought to determine the direct effects IFN-gamma on the differentiation and maturation of human peripheral blood monocyte-derived dendritic cells (moDC). Here, we report that followin...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-47621 | biostudies-arrayexpress
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