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MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
GenomicsTracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer ...
EGAS00001000942 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:03:14:947-502 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. Whole genome shotgun sequencing of fifteen samples, tumour and whole blood, from the four initial patients.
EGAD00001001343 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:06:47:615-508 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. RNA-seq of twelve samples, tumour and benign tissue, from the four initial patients.
EGAD00001001345 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:04:36:707-504 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. Whole genome shotgun sequencing of six samples, tumour and whole blood, from the three additional patients whose somatic variants were examined in depth.
EGAD00001001344 | EGA
GenomicsDAC for integrated genomics of metastatic prostate cancer
Data Access Committee EGAC00001000230
EGAC00001000230 | EGA
GenomicsEGAS00001000262-sc-20170314 - samples
Whole Genome Sequencing Illumina HiSeq data from 111 men with prostate cancer. Samples were taken from primary tissue obtained at prostatectomy (target sequencing depth 50X) with matched blood control (target sequencing depth 30X). This data is from batches 4 to 6.
EGAD00001003225 | EGA
GenomicsThe Natural History of Human Prostate Cancer - samples
Affymetrix SNP6.0 genotype data for prostate cancer patients
EGAD00010000498 | EGA
GenomicsEGAS00001000262-sc-20160408 - samples
To characterize the subclonal genomic architecture of non-androgen-deprived metastatic prostate cancer, we performed whole-genome sequencing (WGS) of pelvic lymph node metastases and matching noncancerous blood from 10 patients to an average sequencing depth of 55x. The patients are part of PELICAN ...
EGAD00001002002 | EGA
GenomicsEGAS00001000262-sc-20131030 - samples
Whole genome DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of 3 men. For each of three different prostates, multiple tumour samples (4, 5, and 3 depending on the case) and one normal tissu...
EGAD00001000689 | EGA
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