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MetabolomicsMetabolomics analysis of the effect of GnRH on the pregnancy rate of ewes with estrus synchronization scheme based on progesterone

Introduction: Gonadotropin-releasing hormone (GnRH) is widely used in the timed artificial insemination program of sheep industry, but there is still controversy about the effect of GnRH on pregnancy rate in the process of artificial insemination. Our research shows that the use of GnRH reduces t...

2024-08-12 | MTBLS10318 | MetaboLights
TranscriptomicsTranscription profiles of cumulus cells from GnRH agonists and GnRH antagonists treated oocytes at different maturity stages
Affymetrix gene expression profiling in cumulus cells (CC) retrieved from patients undergoing GnRH agonists and GnRH antagonists IVF treatment. Oocytes from three different maturity stages were considered: metaphase I oocytes (MI), nonfertilized metaphase II (MII) oocytes (MII-NF) and MII oocytes de...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-34230 | biostudies-arrayexpress
TranscriptomicsEffect of GnRH on miRNA expression in LbetaT2 cells
Mouse immortalized LbetaT2 gonadotrope cells treated with 100 nM GnRH for 2 h. GnRH treated LbetaT2 cells vs. untreated to assess whether GnRH regulates miRNA expression acutely. Treated and untreated RNA labeled independently then hybridized together to 2-color array. Duplicate arrays run with RN...
ORGANISM(S): Mus musculus 
2011-02-18 | E-GEOD-27398 | biostudies-arrayexpress
TranscriptomicsTranscript and protein profiling identify signaling, growth arrest, apoptosis and NFκB-survival signatures following GnRH receptor activation.
Gonadotrophin-releasing hormone (GnRH) significantly inhibits proliferation of a proportion of cancer cell lines by activating GnRH receptor-G protein signaling. Therefore, manipulation of GnRH receptor signaling may have an under-utilized role in treating certain breast and ovarian cancers. However...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-27467 | biostudies-arrayexpress
ModelsVoliotis2019-GnRH Pulse Generation
Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin. Here, using mathematical modeling and in vivo optogenetics we reveal for the first time how this neura...
2024-09-02 | BIOMD0000000931 | BioModels
TranscriptomicsRegulation of LbetaT2 gonadotrope gene expression by GnRH pulses
LbetaT2 cells exposed to different number and concentration of GnRH pulses over 4 hours during in vitro perfusion culture We used MU74Av2 arrays to profile gene expression in response to different pulse frequency and pulse amplitude RNA extracted at end of 4 h of perfusion
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-63251 | biostudies-arrayexpress
TranscriptomicsOptimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes.
Identifying the early gene program induced by GnRH would help understand how GnRH-activated signaling pathways modulate gonadotrope secretory response. We previously analyzed GnRH-induced early genes in LbT2 cells, however these lack GnRH self-potentiation, a physiological attribute of gonadotropes....
ORGANISM(S): Rattus norvegicus 
2011-08-16 | E-GEOD-31399 | biostudies-arrayexpress
ProteomicsIntegrative proteomics and phosphoproteomics analysis of the rat adenohypophysis after GnRH treatment
Quantitative protein proteomics by TMT labeling and phosphorylation enrichment techniques and high-resolution liquid chromatography-mass spectrometry
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD036177 | Pride
Gnrh  proteomics  phosphoproteomics  pituitary  rats 
ModelsRoblitz2013 - Menstrual Cycle following GnRH analogue administration
Roblitz2013 - Menstrual Cycle following GnRH analogue administration The model describes the menstrual cycle feedback mechanisms. GnRH, FSH, LH, E2, P4, inbibins A and B, and follicular development are modelled. The model predicts hormonal changes following GnRH analogue administra...
2024-09-02 | BIOMD0000000494 | BioModels
TranscriptomicsRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells
This experiment was conducted to identify the transcriptome of human GNRH1 cells which has never been reported before and this experiment has identified some novel molecules which might regulate GNRH1 neuron differentiation which could be further explored to identify the origin and development of...
ORGANISM(S): Homo sapiens 
2020-02-16 | E-MTAB-7938 | biostudies-arrayexpress
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