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GenomicsProgressive degeneration of human neural stem cells caused by pathogenic LRRK2
Aging and its physiological manifestations have been correlated with adult stem cell exhaustion and a failure to maintain tissue homeostasis1-10. Since multiple morphological cellular defects are associated with aging-related disorders, we hypothesized that late onset disorders might be linked to ad...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-34061 | biostudies-arrayexpress
GenomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs
To elucidate the transcriptional and epigenetic alterations underlying the neurogenic defects of FA-NSCs, we conducted gene expression microarray analysis and global DNA methylation profiling. The gene expression pattern of gene-corrected NSCs (C-FA-NSCs) resembled that of control-NSCs but clustered...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-57685 | biostudies-arrayexpress
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