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ProteomicsCrosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.
To evaluate the downstream effects of anti-Ly6a crosslinking, we examined the effect of anti-Ly6a antibodies on CD8+ T cell activity in the presence and absence of target tumor cells by high-resolution mass spectrometry proteomic analyses. Spleen cells were isolated from gp10025–33 TCR transgenic mi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-04 | PXD050734 | Pride
Uvb Cd8 t cells Cancer immunotherapy T cells metabolism 
ProteomicsSenescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and limit responsiveness to immunotherapy in mice
Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions, yet the potential for targeting such senescent cells for improved therapy remains largely unknown. Here, we uncover the presence of a senescent subset of cancer-associated fibroblasts (CAFs) within panc...
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD053144 | Pride
: senescence Venetoclax Pancreatic ductal adenocarcinoma (pdac) Senolytics Cancer associated fibroblasts (cafs) Immunotherapy Abt-199 T cells 
ProteomicsSkin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025973 | Pride
Proteomics Uvb light Sexual behavior 
ProteomicsSolar exposed skin induces sex-dependent food-seeking behavior
Considering the distinct physiologies of men and women, it stands to reason that they would react differently to solar exposure, but such a study was never conducted before. Here we show that solar exposure induces food-seeking behavior, food intake and weight gain in males, but not in females, by ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033203 | Pride
Food-seeking Solar exposure Serum 
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