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TranscriptomicsCYP19A1 mediated sex hormone metabolism promotes severe disease outcome in SARS-CoV-2 infected male golden hamsters
Male sex belongs to one of the risk factors for severe COVID-19 outcome. However, underlying mechanisms that could affect sex dependent disease outcome are yet unknown. Here, we identified the CYP19A1 gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (alias aromatase) as a ...
ORGANISM(S): Mesocricetus auratus 
2022-01-21 | E-MTAB-11162 | biostudies-arrayexpress
GenomicsGolden Marseillevirus
Golden Marseillevirus-like: A NEW AMOEBAL GIANT VIRUS
PRJNA296469 | ENA
MetabolomicsA benchmark spike-in data set for biomarker identification in metabolomics
The development and the validation of innovative approaches for biomarker selection are of paramount importance in many -omics technologies. Unfortunately, the actual testing of new methods on real data is difficult, because in real data sets, one can never be sure about the “true” biomarkers. In th...
2013-10-24 | MTBLS59 | MetaboLights
MetabolomicsA multi-omics study on the metabolic reprogramming of a chlorophyll-deficient, high-protein Auxenochlorella pyrenoidosa mutant (CX41) generated by atmospheric and room temperature plasma (ARTP) mutagenesis.

This project aims to elucidate the molecular mechanism underlying the stable golden-yellow phenotype and enhanced protein accumulation in an Auxenochlorella pyrenoidosa mutant (CX41) generated by ARTP mutagenesis. Through comparative analysis between the wild-type (FACHB-9) and mutant s...

2025-12-26 | MTBLS13574 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
ProteomicsAn Integrated Transcriptome and Proteome Analysis Reveals New Insights of Fruit Russeting Formation in ‘Golden Delicious’ Apple
Russeting of apple fruit is a non-invasive physiological disorder. It occurs mainly in 'Golden Delicious' apple and its hybrids, while understanding of its molecular mechanism is still limited. In this study, we used mRNA sequencing and an isobaric tag for relative and absolute quantitation-based qu...
ORGANISM(S): Rosaceae 
2019-09-26 | PXD014960 | Pride
Fruit russeting formation  transcriptome  proteome  ‘golden delicious’ apple  lignin biosynthesis 
TranscriptomicsGenome-wide transcriptomic profiles of the lungs of SARS-CoV-2 infected hamsters treated with the CYP19A1 inhibitor letrozole.
Male and female golden hamsters (n = 5 per group) were either control (PBS) treated or infected with SARS-CoV-2 (105 pfu), following treatment with vehicle or the CYP19A1 (aromatase) inhibitor letrozole for 8 consecutive days. At 21 days post infection, animals were sacrificed; subsequently, the lun...
ORGANISM(S): Mesocricetus auratus 
2023-06-30 | E-MTAB-13100 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of barley roots and shoots from the cultivars Maythorpe and Golden Promise grown under normal and high salinity conditions
Salt Stress response of salt-tolerant genotype Golden Promise compared to Maythorpe; Barley1 GeneChip was used to find differential expression between two barley genotypes under control and salt stress conditions at vegetative stage of growth Experiment Overall Design: Roots (tips) and shoot (crown ...
ORGANISM(S): Hordeum vulgare 
2007-10-24 | E-GEOD-6325 | biostudies-arrayexpress
GenomicsMalus domestica strain:golden delicious
Golden Delicious WGS
PRJNA28845 | ENA
TranscriptomicsGolden snub-nosed monkey transcriptome data used for gene annotation
To optimize the golden snub-nosed monkey genome annotation, one RNA library of mixed tissues from one individual were constructed using the Illumina mRNA-Seq Prep Kit. We sequenced mixed tissues using the Illumina HiSeq 2000 platform.
ORGANISM(S): Rhinopithecus roxellana 
2014-10-19 | E-GEOD-53597 | biostudies-arrayexpress
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