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GenomicsGenomic study of an AT-AML
Ataxia Telangiectasia (A-T) is caused by biallelic mutations in ATM and confers predisposition to cancer, with acute myeloid leukaemia (AML) being rarely observed. We investigated an AML arising in an A-T patient for secondary genetic events by performing whole exome sequencing of serial samples ove...
EGAS00001004392 | EGA
Genomics98be40b5-5141-4ceb-8723-6ddc59a9cda6 - samples
Serial samples from one AT-AML patient as described in publication Goldgraben et al Pediatric Blood & Cancer 2020. Whole exome sequencing of a AT-'germline' blood sample, one bone marrow sample (at AML diagnosis) and 3 AML blood samples. Library preped using the Illumina Nextera Rapid Capture Exom...
EGAD00001006090 | EGA
GenomicsData from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
The transforming growth factor beta (TGFβ) signalling pathway exerts opposing effects on cancer cells, acting either as a tumor-promoter or as a tumor-suppressor. Here we show these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGFβ signalling, and the distinct...
EGAS00001001570 | EGA
GenomicsZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification ...
EGAS00000000082 | EGA
GenomicsSmadChip
Smad3
EGAD00010000859 | EGA
Genomicsena-DATASET-CRUK-CI-11-11-2015-15:28:33:473-12 - samples
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
EGAD00001001668 | EGA
Genomicsena-DATASET-CRUK-CI-11-11-2015-14:57:45:115-9 - samples
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
EGAD00001001667 | EGA
Genomicsena-DATASET-CRUK-CI-11-11-2015-15:29:28:770-13 - samples
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
EGAD00001001669 | EGA
GenomicsInherited Predisposition to Cancer Projects Data Access Committee
Data Access Committee EGAC00001001565
EGAC00001001565 | EGA
GenomicsPol2Chip
Pol2
EGAD00010000860 | EGA
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