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TranscriptomicsTranscription profiling of mouse tendon, cornea, and skin fibroblasts stimulated with mechanical stress to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another.
In order to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another, we have subjected tendon, skin and corneal fibroblasts of fetal mouse to mechanical stimulation by fluid flow and analyzed the transcriptional responses of the cells using Affymetrix...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3486 | biostudies-arrayexpress
TranscriptomicsComplementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation.
OBJECTIVE: Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate. METHODS: We compared the transcriptional profiles of freshly sorted adult human white matter progenitor cells (WMPCs), purified ...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26535 | biostudies-arrayexpress
TranscriptomicsProspective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting
Sox2 is expressed by neural stem and progenitor cells, and a sox2 enhancer identifies these cells in the forebrains of both fetal and adult transgenic mouse reporters. We found that an adenovirus encoding EGFP placed under the regulatory control of a 0.4 kb sox2 core enhancer selectively identified ...
ORGANISM(S): Homo sapiens 
2011-02-25 | E-GEOD-27505 | biostudies-arrayexpress
TranscriptomicsFate determination of adult human glial progenitor cells
Glial progenitor cells comprise the most abundant population of progenitor cells in the adult human brain. They are responsible for CNS remyelination, and likely contribute to the astrogliotic response to brain injury and degeneration as well. Adult human GPCs are biased to differentiate as oligoden...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-36634 | biostudies-arrayexpress
ProteomicsKinome profiling: cabozantinib treatment in a mouse model of plexiform neurofibroma
Neurofibromatosis type 1 (NF1) is the most common autosomal dominant disorder, affecting 1 in 3,500 individuals worldwide and predisposing to cancer. Germline mutations in the NF1 gene, encoding the p21Ras GTPase-activating protein (GAP) neurofibromin, are the underlying cause for NF1. Somatic inact...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-18 | PXD019005 | Pride
Receptor tyrosine kinase Nf1 Xl184 
UnknownA phase I trial of lenalidomide and radiotherapy in children with diffuse intrinsic pontine gliomas or high-grade gliomas.
Not available
S-EPMC7690216 | biostudies-literature
GenomicGenome-Wide Association Study of Anorexia Nervosa

Twin studies are consistent with substantial heritability in anorexia nervosa (AN), although detecting and confirming individual risk alleles has been difficult, due to small effects of single alleles and limited samples in prior studies.

Methods: 1105 AN DNA samples obtained in a m...

phs000679 | dbGaP
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