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TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-18 | E-GEOD-28617 | biostudies-arrayexpress
TranscriptomicsNovel viruses naturally infecting Caenorhabditis nematodes trigger a small RNA response
C. elegans has served as a laboratory model organism due to its ease of manipulation and the availability of both forward and reverse genetics. In recent years, efforts to study host-pathogen interactions in C. elegans have increased. For example, analysis of infections by bacteria such as Pseudomon...
ORGANISM(S): Caenorhabditis elegans 
2011-01-01 | E-GEOD-21736 | biostudies-arrayexpress
TranscriptomicsExpression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants
Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-L...
ORGANISM(S): Caenorhabditis elegans 
2013-11-14 | GSE52340 | GEO
UnknownArchitecture of the cortical actomyosin network driving apical constriction in C. elegans.
Not available
S-EPMC9915510 | biostudies-literature
TranscriptomicsExpression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants
Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-...
ORGANISM(S): Caenorhabditis elegans 
2013-11-14 | E-GEOD-52340 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (mRNA)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-17 | E-GEOD-37432 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs
This SuperSeries is composed of the following subset Series: GSE28617: Function, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq) GSE37432: Function, targets and evolution of Caenorhabditis elegans piRNAs (mRNA) Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2012-06-17 | E-GEOD-37433 | biostudies-arrayexpress
UnknownIL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.
Not available
S-EPMC3132139 | biostudies-literature
UnknownEngineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.
Not available
S-EPMC7588011 | biostudies-literature
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