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The Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking fluxes converge. The mechanism by which cargo and Golgi-resident proteins traverse this organelle has long been debated. Recent discoveries have identified a molecular machinery that...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064301 | Pride
Effects of GOLPH3 knock-out on the mouse liver transcriptomic profile
Glycosylation plays an important role for modifications of lipids and sorting of proteins that is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi enzymes. We found that cells lacking the Golgi N-acetylglucosamine phosphotransferase (GNPT) retention factor LYSET/...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD052083 | Pride
Next Generation Sequencing Facilitates Quantitative Analysis of Vector and GOLPH3 Transcriptomes
The Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long been debated. Recent studies have identified a molecular machinery that sorts resident proteins into ...
ORGANISM(S): Mus musculus 
2026-04-23 | GSE327245 | GEO
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived HCT-116 cell transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods...
ORGANISM(S): Homo sapiens 
2022-02-23 | GSE196875 | GEO
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