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ProteomicsBlood-brain barrier dysfunction in brain metastasis formation in HER2-positive breast cancer
we investigated the role of bioactive molecules secreted by HER2+ BC cells in BBB dysfunction during the formation of the pre-metastatic niche before the onset of BrM. We demonstrate that systemic signaling derived from brain metastatic HER2+ primary tumors instigates BBB dysfunction
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051579 | Pride
Her2+ breast cancer Bbb dysfunction Brain metastasis Secretome 
TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
UnknownLipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle.
Not available
S-EPMC6214003 | biostudies-literature
TranscriptomicsIdentification of small non-coding RNAs in zebrafish
MicroRNAs (miRNAs) are a new class of small RNAs of approximately 22 nucleotides in length that control eukaryotic gene expression by fine tuning mRNA translation. They regulate a wide variety of biological processes, namely developmental timing, cell differentiation, cell proliferation, immune resp...
ORGANISM(S): Danio rerio 
2016-03-31 | E-GEOD-66718 | biostudies-arrayexpress
ProteomicsAge-induced methylmalonic acid accumulation promotes cancer aggressiveness and metastatic disease
TMT protein abundance profiling of human serum from 30 young and 30 older adults.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-18 | MSV000084974 | MassIVE
UnknownMultifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission: The MESSAGE-HF Randomized Clinical Trial.
Not available
S-EPMC10701668 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownPancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries.
Not available
S-EPMC10771125 | biostudies-literature
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