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ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
UnknownPhase II Study of Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) As Part of Lung-Sparing Multimodality Therapy in Patients With Malignant Pleural Mesothelioma.
Not available
S-EPMC5019761 | biostudies-literature
ProteomicsHowDirty: An R package to evaluate molecular contaminants in LC-MS experiments
Contaminants derived from consumables, reagents, and sample handling often negatively affect LC-MS data acquisition. In proteomics experiments, they can markedly reduce identification performance, reproducibility, and quantitative robustness. Here, we introduce a data analysis workflow combining MS1...
ORGANISM(S): Homo Sapiens (human) 
2023-10-12 | PXD044032 | JPOST Repository
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Ras IP
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012505 | Pride
Hras hrasv12 hela 
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Phosphoproteomics
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012506 | Pride
Ras phosphoproteomics minetei localisation 
ProteomicsInhaled Multi-Walled Carbon Nanotubes modulate differently global gene and protein expression in lung rats
Multi-walled carbon nanotubes (MWCNTs) are among the most promising nanomaterials because of their physical and chemical properties. However, since they are biopersistent fiber-like materials which share similarities with asbestos, concerns have arisen about their health effects. With their various ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-04 | PXD018900 | Pride
Multi-walled carbon nanotubes Proteomics Rat Inhalation Transcriptomics 
ProteomicsIP C5ORF30 macrophage immunometabolism regulator gene
Expression of the macrophage immunometabolism regulator gene (MACIR) is associated with severity of autoimmune disease pathology and the regulation of macrophage biology through unknown mechanisms. The 206 amino acid protein lacks homology to any characterized protein sequence and is a disordered pr...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD016878 | Pride
Ip c5orf30 macir human rheumatoid arthritis 
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