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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsExpression and functional validation of new p38α transcriptional targets in tumorigenesis
p38α MAP kinase plays an important tumor suppressor role, which is mediated by both its negative effect on cell proliferation and its pro-apoptotic activity. Surprisingly, most tumor suppressor mechanisms coordinated by p38α have been reported to occur at the post- translational level. This contrast...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-26762 | biostudies-arrayexpress
GenomicsGenome wide profiling of PAX8 binding stes in PCCL3 rat cells
Analysis of PAX8 binding sites by chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq) in PCCL3 rat cells. Results provide insight into the contribution of this regulatory factor to transcription genome-wide. We generate a genome wide map of PAX8 binding sites in PC...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-26871 | biostudies-arrayexpress
TranscriptomicsEffect of ARF on the transcription of p53 target genes in homologous recombination deficient cells
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. In this work we show that homologous recombination (HR) -deficient primary mouse and human cells accumulate...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-51354 | biostudies-arrayexpress
TranscriptomicsMolecular Signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17-AAG, in breast cancer.
We have done transcriptional profiling of 17-AAG treated (24h, 48H) breast cancer cell lines to understand the mechanisms of the drug action and indicate novel set of pharmacodynamic biomarkers of the drug response as well as of resistance Two-condition experiment, Untreated vs. Treated sensitive c...
ORGANISM(S): Homo sapiens 
2010-10-11 | E-GEOD-23209 | biostudies-arrayexpress
GenomicsA unique role of Cohesin-SA1 in gene regulation and development [ChIP-Seq]
Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome wide distribution of cohesin in wild-type and SA1-null c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32319 | biostudies-arrayexpress
TranscriptomicsA unique role of Cohesin-SA1 in gene regulation and development [Expression]
Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome wide distribution of cohesin in wild-type and SA1-null c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32234 | biostudies-arrayexpress
TranscriptomicsA unique role of Cohesin-SA1 in gene regulation and development
This SuperSeries is composed of the following subset Series: GSE32234: A unique role of Cohesin-SA1 in gene regulation and development [Expression] GSE32319: A unique role of Cohesin-SA1 in gene regulation and development [Chip-Seq] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32320 | biostudies-arrayexpress
UnknownNIR-Emitting Cyclometalated Cp*-Ir(III) Complexes: Impact of Ligand π-Extension on Aggregation Behavior and Photophysical Properties.
Not available
S-EPMC12914635 | biostudies-literature
UnknownCardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome.
Not available
S-EPMC8614561 | biostudies-literature
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