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TranscriptomicsKnockdown of Atoh8 in Neurog3-expressing mouse ductal cells mPAC results in altered expression of multiple cell cycle related genes
Atoh8 is a transcription factor of the basic-helix-loop-helix (bHLH) family that is expressed in multiple tissues during embryonic development but whose specific functions remain unknown. The gene encoding Atoh8 is induced by various lineage- determining bHLH transcription factors in cell culture, ...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-43536 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44047 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes β-Cell Proliferation [10 days]
Obesity is associated with an increase in β-cell mass in response to the rising demand for insulin. β-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which β-cell mass is regulated remain poorly understood. Recently, we described the...
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44045 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation [30 days]
Obesity is associated with an increase in ?-cell mass in response to the rising demand for insulin. ?-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which ?-cell mass is regulated remain poorly understood. Recently, we described the...
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44046 | biostudies-arrayexpress
TranscriptomicsThe role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice
AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31150 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreatic beta cell line (MIN6) treated with amylin at different times and doses and growth at different concentrations of glucose
Murine pancreatic beta cell line MIN6 was growth at two different concentrations of glucose (22,2 and 5,5 mM of glucose), 37ºC, 5% CO2 and was treated at four different concentrations of human amylin (0, 1, 10 and 20 uM) during three different times (2, 12 and 24 hours)
ORGANISM(S): Mus musculus 
2009-04-10 | E-GEOD-2253 | biostudies-arrayexpress
TranscriptomicsEffects of sodium tungstate administration in Irs2 -/- mice
Relative beta cell deficit and increased beta cell apoptosis are hallmarks of type 2 diabetes (T2D). The Insulin/Insulin Growth Factor (Igf) signaling pathway is an established regulator of beta cell survival and is found downregulated in human T2D islets. The Insulin Receptor Substrate 2 (Irs2) pla...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-43620 | biostudies-arrayexpress
UnknownStructural and Lattice-Dynamical Properties of Tb2O3 under Compression: A Comparative Study with Rare Earth and Related Sesquioxides.
Not available
S-EPMC7588034 | biostudies-literature
UnknownDirect reprogramming of human fibroblasts into insulin-producing cells using transcription factors.
Not available
S-EPMC10039074 | biostudies-literature
TranscriptomicsINDUCTION OF PANCREATIC ISLET CELL DIFFERENTIATION BY THE NEUROGENIN-NEUROD CASCADE
Neurog3 and NeuroD1 share the ability to induce endocrine differentiation when expressed ectopically in vivo (Apelqvist et al., 1999; Schwitzgebel et al., 2000; Grapin-Botton et al., 2001) and in vitro (Heremans et al., 2002; Gasa et al., 2004), suggesting that they target a common set of genes. To...
ORGANISM(S): Mus musculus 
2007-08-29 | E-GEOD-7884 | biostudies-arrayexpress
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