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TranscriptomicsTranscription profiling of gonadotrope pituitary tumors identifies Growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors
Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26966 | biostudies-arrayexpress
ProteomicsA distal activin-responsive super-enhancer regulates Fshb transcription and gonadotrope differentiation
A large “gene desert” located far upstream from Fshb and Kcna4 contains several gonadotrope-specific accessible chromatin sites which, in chromatin conformation capture (3C), were seen to make distinct contacts with both genes. The region displays several features of a super-enhancer and both genes ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD072033 | Pride
Activin Fsh Gonadotrope differentiation 
UnknownIdentification of a pituitary ERα-activated enhancer triggering the expression of Nr5a1, the earliest gonadotrope lineage-specific transcription factor.
Not available
S-EPMC6685283 | biostudies-literature
UnknownIntronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model.
Not available
S-EPMC9820228 | biostudies-literature
UnknownThe HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
Not available
S-EPMC5416990 | biostudies-literature
TranscriptomicsFoxl2 preserves chromatin accessibility at a distal super-enhancer which regulates the Fshb-Kcna4 locus
A large “gene desert” located far upstream from Fshb and Kcna4 contains several gonadotrope-specific accessible chromatin sites which were seen in chromatin conformation capture (3C) to make distinct contacts with both genes. Expression of Fshb and Kcna4 was strongly inhibited by JQ-1, which repress...
ORGANISM(S): Mus musculus 
2026-03-16 | GSE315967 | GEO
UnknownOocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells.
Not available
S-EPMC4262775 | biostudies-literature
UnknownHes1 is required for pituitary growth and melanotrope specification.
Not available
S-EPMC1913046 | biostudies-literature
UnknownActivin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation.
Not available
S-EPMC2673912 | biostudies-literature
UnknownFOXO1 regulates expression of Neurod4 in the pituitary gland.
Not available
S-EPMC10922409 | biostudies-literature
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