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ProteomicsToxoplasma gondii Tgj1 Hsp40 protein interaction LC-MS/MS
We identified an Hsp40 Ydj1 / Hdj2 ortholog in T. gondii, which is involved in various biological roles in T. gondii as deduced from its interactome and analysis of the ΔCXXX mutant. Among these roles are differentiation and DNA damage, as well as metabolic pathways such as translation and energy ge...
ORGANISM(S): Toxoplasma gondii 
2023-05-10 | PXD024656 | Pride
Toxoplasma Gondii hsp40 Interaction 
TranscriptomicsToxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into ...
ORGANISM(S): Toxoplasma gondii 
2011-05-25 | E-GEOD-22100 | biostudies-arrayexpress
TranscriptomicsExpression data from host cells infected with different strains of Toxoplasma gondii
This SuperSeries is composed of the following subset Series: GSE25468: Expression data from Human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii. GSE25469: Expression data from WT or p65-/- mouse embryonic fibroblasts (MEFs) infected with Toxoplasma gondii. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25476 | biostudies-arrayexpress
UnknownAnalysis of the Interactome of the <i>Toxoplasma gondii</i> Tgj1 HSP40 Chaperone.
Not available
S-EPMC10056330 | biostudies-literature
TranscriptomicsThe Toxoplasma unfolded protein response
To characterize the nature of the unfolded protein response in this Toxoplasma, we carried out microarray analyses to measure the changes in the transcriptome and in translational control during ER stress. Total RNA or RNA fractionated into monosomes or polysomes were purified from parasites treated...
ORGANISM(S): Toxoplasma gondii 
2013-05-24 | E-GEOD-43722 | biostudies-arrayexpress
TranscriptomicsExpression data from Human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription. HFFs were infe...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-25468 | biostudies-arrayexpress
TranscriptomicsExpression data from WT or p65-/- mouse embryonic fibroblasts (MEFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription, and whether th...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25469 | biostudies-arrayexpress
TranscriptomicsExpression data from RAW264.7 murine macrophages infected with Toxoplasma gondii and subsequently stimulated with interferon-gamma
Toxoplasma strains are known to inhibit the expression of several interferon-gamma induced genes, and a type II strain was shown to dysregulate genome-wide responses to interferon-gamma in human fibroblasts (Kim et al., 2007, J Immunol.). In this study we aimed to determine the effect of infection ...
ORGANISM(S): Mus musculus 
2013-02-19 | E-GEOD-34913 | biostudies-arrayexpress
TranscriptomicsExpression Data from Toxoplasma gondii-Infected Murine Bone Marrow-Derived Macrophages
We wanted to determine how type II Toxoplasma GRA15 and type I ROP16 affect host gene expression. We infected bone marrow-derived macrophages (BMMs) from B6 mice with type II (Pru), type II +ROP16 I, type II ?gra15, or type II ?gra15 + ROP16I. BMMs were plated, then infected with parasites for 18 ho...
ORGANISM(S): Mus musculus 
2011-05-20 | E-GEOD-29404 | biostudies-arrayexpress
TranscriptomicsExpression Data from Toxoplasma gondii Infected Murine Macrophages and Dendritic Cells
We wanted to determine how type II versus type III Toxoplasma infection affect host gene expression We infected mouse macrophage (RAW264.7 and J774) and dendritic (DC2.4) cell lines with type II (Me49) and type III (CEP) cells were grown in T75 until 80% confluency, then infected with parasites for ...
ORGANISM(S): Mus musculus 
2011-05-29 | E-GEOD-29584 | biostudies-arrayexpress
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