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Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
ProteomicsOsteopontin Regulation of MerTK+ Macrophages Promotes Crohn’s Disease Intestinal Fibrosis
The pathogenesis of intestinal fibrosis in Crohn’s disease (CD) remains unclear. Mer receptor tyrosine kinase (MerTK) is an immunosuppressive protein specifically expressed in macrophages. Osteopontin (OPN), also known as secreted phosphoprotein 1, contributes to inflammation and wound repair. This ...
ORGANISM(S): Mus Musculus 
2024-05-31 | PXD052743 |
ProteomicsCullin 4b modulates Wnt signaling and CRL4b targets Irgm1 to fuel intestinal stem cell stemness and niche
Background & Aims: Hierarchical organization of intestine relies on their stem cells by self-renew and producing committed progenitors. Although signals like Wnt are known to animate the continued renewal by maintaining intestinal stem cells (ISCs) activity, molecular mechanisms especially E3 ubiqui...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD021528 | Pride
Cul4b  intestinal stem cells (iscs)  irgm1  stem cell niche 
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