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ProteomicsThe CRL4B E3 ubiquitin ligase complex regulates mitosis by recruiting phospho-specific DCAFs
The cullin scaffolds CUL4A and CUL4B assemble E3-ligase complexes regulating multiple mostly chromatin-associated cellular functions. Although they are structurally similar, we found that the unique N-terminal extension of CUL4B is heavily phosphorylated during mitosis, and this pattern is perturbed...
ORGANISM(S): Homo sapiens (Human) 
2023-06-15 | PXD035329 | Pride
Mitosis Dcaf E3 ubiquitin ligase Spindle positioning Phosphorylation Cell cortex Cell cycle regulation 
ProteomicsCul4b promotes CD4 T cell expansion by aiding the repair of damaged DNA
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. We have identified an E3 ubiquitin ligase, Cul4b, that regul...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD017699 | Pride
Dcaf1 Crl4 E3 ubiquitin ligase T cell receptor Apoptosis Smc1a Cul4b Cell cycle T cells Proliferation Adaptive immune response Dna damage response 
Proteomicsc-Myc uses Cul4b to preserve genome stability and promote CD8+ T cell-mediated antiviral immune responses
During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk for replication-induced DNA damage. We found that c-Myc util...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD041220 | Pride
C-myc Cd8+ t cells Replication stress Antiviral immune responses E3 ubiquitin ligases Cul4b 
GenomicsCUL4B ChIP-sequencing in non-treated MDA-MB-231 cells
CUL4B ChIP-sequencing in non-treated MDA-MB-231 cells
PRJNA512839 | ENA
GenomicsRNA sequencing of human breast cancer cells with CUL4B knockdown
RNA sequencing of human breast cancer cells with CUL4B knockdown
PRJNA666132 | ENA
GenomicsMicroRNA expression in CUL4B-depleted LNCaP cells and control
MicroRNA expression in CUL4B-depleted LNCaP cells and control
PRJNA532609 | ENA
TranscriptomicsChIP-on-chip from MDA-MB-231 cells with PHF1, CUL4B and PRMT5
It has been reported that PHF1, CUL4B and PRMT5 all play important roles in epigenetic regulation. We reported that PHF1, CRL4B and PRMT5 may act as a complex in transcriptional regulation and have a vital effect in breast cancer progression. So we performed ChIP-on-chip assays to find unique promot...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-84071 | biostudies-arrayexpress
GenomicsMicroRNA expression in CUL4B-depleted LNCaP cells and control
We examined a global miRNA expression in CUL4B-depleted LNCaP cells to identify miRNA(s) regulated by CUL4B.
ORGANISM(S): Homo sapiens 
2019-04-13 | GSE129737 | GEO
GenomicsCUL4B ChIP-sequencing in non-treated MDA-MB-231 cells
Cullin 4B (CUL4B) is a scaffold protein of the CUL4B-Ring E3 ligase (CRL4B) complex. Here, we found that CRL4B interacted with transcriptional corepressor complexes. Our results supporting CUL4B as a potential target of cancer therapy.
ORGANISM(S): Homo sapiens 
2021-03-25 | GSE124611 | GEO
TranscriptomicsOverexpression of CUL4B promotes gastric cancer metastasis through upregulation of HER2
Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, has been reported to be overexpressed in several types of solid tumors and contributes to epigenetic silencing of tumor suppressor. However, its clinical significance and the molecular mechanisms underlying its re...
ORGANISM(S): Homo sapiens 
2017-11-25 | GSE90501 | GEO
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