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ProteomicsPulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ~20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates....
ORGANISM(S): Homo sapiens (Human) 
2023-10-11 | PXD042903 | Pride
Pulse-silac Dcafs Ubiquitination Bioid Ddb1 Interactome Cullin4 
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...
ORGANISM(S): Cellular Organisms 
2022-12-15 | PXD033366 | JPOST Repository
GenomicsHomo sapiens
Identification of DCAF substrates using lysates of knockdown cells
PRJDB35474 | ENA
UnknownDevelopment of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.
Not available
S-EPMC6429600 | biostudies-literature
UnknownRaf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.
Not available
S-EPMC3271066 | biostudies-literature
UnknownThe components of Drosophila histone chaperone dCAF-1 are required for the cell death phenotype associated with rbf1 mutation.
Not available
S-EPMC3789789 | biostudies-literature
UnknownStructural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Not available
S-EPMC9975947 | biostudies-literature
UnknownExpression profiling of WD40 family genes including DDB1- and CUL4- associated factor (DCAF) genes in mice and human suggests important regulatory roles in testicular development and spermatogenesis.
Not available
S-EPMC7457511 | biostudies-literature
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion mutagenesis...
ORGANISM(S): Cytomegalovirus Rat cytomegalovirus ALL-03 Rattus norvegicus (Rat) 
2022-12-09 | PXD033639 | Pride
Interferon  ubiquitin-proteasome system  cullin-ring ubiquitin ligases (crl)  ddb1  dcafs  viral dcaf (vdcaf)  antiviral  cytomegalovirus (cmv)  stat2  irf9   
TranscriptomicsTranscriptome and analysis of Wdr70 deletion by next-generation sequencing
CRL4 is a family of SCF-like ubiquitin ligase constituted by Cul4-Ddb1-RING finger scaffold and DCAF substrate adaptors. We revealed Wdr70 as a novel DCAF protein that assembles with Cul4-Ddb1 and functions as chromatin remodeling factor in Schizosaccharomyces pombe.Besides its function in DNA repai...
ORGANISM(S): Schizosaccharomyces pombe 
2016-04-04 | E-GEOD-79830 | biostudies-arrayexpress
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