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ProteomicsIP-MS of DCAF1/VprBP interacting proteins in mouse CD4 T cells
DCAF1, also known as VprBP (HIV-1-viral-protein-r-binding-protein), is an evolutionary conserved substrate-binding subunit of CRL4 (Cul4a-Ddb1-Roc1) ubiquitin ligase complex. It is a cellular protein targeted by HIV-1 viral protein R (Vpr). DCAF1 modulates cellular response against HIV in macrophage...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-12 | PXD003180 | Pride
Dcaf1 T cell Vprbp Hiv-1 
TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
GenomicsVprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
PRJNA961784 | ENA
TranscriptomicsVprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
DCAF1, also known as VprBP, is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing the risk for colon and prostate cancers. Melanoma is the most aggressive form of skin cancer arising from pigment-produ...
ORGANISM(S): Homo sapiens 
2023-05-05 | GSE230573 | GEO
ProteomicsDCAF1 interacting partners in myeloma cells
Multiple myeloma is a plasma cell malignancy that is susceptible to drugs targeting protein homeostasis such as thalidomide analogues and proteasome inhibitors. Thalidomide analogues modulate the activity of DDB1/CUL4 E3-ligase complexes to perturb substrate recognition and proteasomal degradation t...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD066365 | Pride
Human jjn3 myeloma cells  dcaf1/vprbp 
ProteomicsDCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug discovery. So far only a few ligases have been utilized for ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD046286 | Pride
Tmt Dcaf1 Tpd Protac 
UnknownCrystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Not available
S-EPMC11585590 | biostudies-literature
ProteomicsCharacterisation of VPRBP/DCAF1 kinase inhibitor analogues
Multiple myeloma is a plasma cell malignancy that is susceptible to drugs targeting protein homeostasis such as thalidomide analogues and proteasome inhibitors. Thalidomide analogues modulate the activity of DDB1/CUL4 E3-ligase complexes to perturb substrate recognition and proteasomal degradation t...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD061427 | Pride
Dcaf1 Proteomics Myeloma 
UnknownDiscovery of Nanomolar DCAF1 Small Molecule Ligands.
Not available
S-EPMC10108359 | biostudies-literature
GenomicsDCAF1 regulates Treg senescence via the ROS axis during immunological aging
DCAF1 regulates Treg senescence via the ROS axis during immunological aging
PRJNA540226 | ENA
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