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TranscriptomicsGenome-wide expression analysis of VprBP knockdown in DU145 cells
VprBP has been implicated in transcriptionally silent chromatin formation and cell cycle regulation, but the molecular basis underlying such effects remains unclear. To investigate the role of VprBP on gene regulation, genme-wide gene expression analysis is carried out in DU145 cells expressing eith...
ORGANISM(S): Homo sapiens 
2013-11-07 | E-GEOD-50414 | biostudies-arrayexpress
GenomicsVprBP regulates osteoclast differentiation via histone H2A phosphorylation
VprBP regulates osteoclast differentiation via histone H2A phosphorylation
PRJNA1152008 | ENA
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040477 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040473 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
GenomicsVprBP directs epigenetic gene silencing through H2A phosphorylation in colon cancer
VprBP directs epigenetic gene silencing through H2A phosphorylation in colon cancer
PRJNA747687 | ENA
TranscriptomicsVprBP regulates osteoclast differentiation via histone H2A phosphorylation
Bone remodeling is a continuous and balanced process which relies on the dynamic equilibrium between osteoclastic bone resorption and osteoblastic bone formation. During osteoclast differentiation, pro-osteoclastogenic and anti-osteoclastogenic genes are selectively targeted by positive and negative...
ORGANISM(S): Mus musculus 
2025-01-28 | GSE275603 | GEO
TranscriptomicsGenome-wide expression analysis of VprBP knockdown in DU145 cells
VprBP has been implicated in transcriptionally silent chromatin formation and cell cycle regulation, but the molecular basis underlying such effects remains unclear. To investigate the role of VprBP on gene regulation, genme-wide gene expression analysis is carried out in DU145 cells expressing eith...
ORGANISM(S): Homo sapiens 
2013-11-07 | GSE50414 | GEO
GenomicsPhosphorylation and stabilization of EZH2 by VprBP trigger aberrant gene silencing in colon cancer
Phosphorylation and stabilization of EZH2 by VprBP trigger aberrant gene silencing in colon cancer
PRJNA791646 | ENA
GenomicsIdentification of highly potent inhibitors capable of blocking VprBP kinase activity and suppressing prostate tumor growth
Identification of highly potent inhibitors capable of blocking VprBP kinase activity and suppressing prostate tumor growth
PRJNA1330837 | ENA
UnknownVprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation.
Not available
S-EPMC10526264 | biostudies-literature
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