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MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
ProteomicsIdentifying interactors of IRF1 and STAT1 during type I and type II interferon treatment using proximity-dependent labeling
Identifying interactors of IRF1 and STAT1 in bone marrow-derived macrophages during type I and type II interferon treatment using the proximity-dependent labeling approach TurboID followed by Mass Spectrometry
ORGANISM(S): Mus musculus (Mouse) 
2024-03-12 | PXD040337 | Pride
Turboid Interactors Irf1 Ifn-ii Ifn-i Stat1 
TranscriptomicsOncogenic Ras inhibits IRF1 to promote viral oncolysis
Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-mediated antiviral responses are known to be the major mechanisms underlying viral oncolysis. Previous...
ORGANISM(S): Mus musculus 
2014-11-13 | E-GEOD-49469 | biostudies-arrayexpress
ProteomicsIRF1 acetylation sites by KAT8
Aim to identify the IRF1 acetylation site by KAT8 in cotransfected HEK293T cells
ORGANISM(S): Homo Sapiens 
2022-12-05 | PXD038568 |
TranscriptomicsImpact of IRF1 on transcriptome changes in Huh-7 human hepatoma cells and STAT1-deficient human fibroblasts
IRF1, and interferon-induced transcription factor, was found to have antiviral activity against a range of viruses when overexpressed. To determine which genes are associated with expression of IRF1, gene expression analysis was carried out in two different cell line expressing IRF1. The results sho...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-26817 | biostudies-arrayexpress
GenomicsIRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression
IRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression
PRJNA1431227 | ENA
TranscriptomicsSTAT1 and IRF1 enrichment in naive and primed HeLa cells upon IFNγ treatment
STAT1 and IRF1 transcription factor enrichment by CUT&RUN. HeLa cells were primed with IFNγ for 24 hours, followed with IFNγ washout. After 48h, naïve and primed cells were induced by IFNγ for 1h and 3h. Cells were harvested at indicated time points and processed for CUT&RUN
ORGANISM(S): Homo sapiens 
2023-05-06 | E-MTAB-12625 | biostudies-arrayexpress
ProteomicsIRF1 mass-spectrometry primary fibroblasts non-stimulated or stimulated with IFNg for 24h
Inborn errors of human IFN-γ immunity underlie mycobacterial diseases, whereas inborn errors of IFN-a/b immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe two unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, lif...
ORGANISM(S): Homo sapiens (Human) 
2023-01-19 | PXD037759 | Pride
Fibroblasts Ifng Lc-ms 
GenomicsIRF1 regulates IFN dependent and independent gene expression
IRF1 regulates IFN dependent and independent gene expression
PRJNA470803 | ENA
GenomicsIRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression [ChIP-seq]
IRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression [ChIP-seq]
PRJNA1462346 | ENA
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