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MetabolomicsUrinary Ubiquitin-Specific Protease 2 (USP2) as a Diagnostic Biomarker for Chronic Kidney Disease: An Integrated Multi-Omics and Network Analysis
Urinary USP2 is elevated in chronic kidney disease and shows strong diagnostic performance. Integrated metabolomics and proteomics analyses identified cortisol and prostaglandin A3 as candidate mediators and linked USP2 to lipid metabolism and ferroptosis-related pathways.
2026-05-05 | MTBLS14426 | MetaboLights
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040477 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
TranscriptomicsTranscriptome analysis on whole kidney of Usp2 knockout mice
Ubiquitylation plays an important role in the control of Na+ homeostasis by the kidney. It is well established that the epithelial Na+ channel ENaC is regulated by the ubiquitin-protein ligase NEDD4-2, limiting ENaC cell surface expression and activity. Ubiquitylation can be reversed by the action o...
ORGANISM(S): Mus musculus 
2013-01-16 | E-GEOD-43517 | biostudies-arrayexpress
ProteomicsIdentification of Drosophila USP2 partners
We used Drosophila flies model system for the identification of new enzymes of the ubiquitin specific protease family regulating evolutionary conserved immune signals in both Drosophila and Humans. These enzymes specifically control the stability or the activated status of target proteins by hydroly...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2014-07-18 | PXD000881 | Pride
Usp2 Pull-down Nanolc-ms/ms Drosophila melanogaster 
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040473 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
TranscriptomicsEffects of supernatants of USP2 knockdown HL-60 cells and mock transfected HL60 cells on differentiated 3T3-L1 cells
Ubiquitin specifc protease (USP) 2 modulates various cellular responces including carcinogenesis, spermatogenesis, and glucose metabolism. So far, we established USP2 knockdown HL-60 cells to explore roles of USP2 in macrophages. In this experiment, we investigated whether USP2 knockdown HL-60 cells...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-43313 | biostudies-arrayexpress
TranscriptomicsUsp2-KO whole kidney microarray ZT12
Renal transcriptome analysis of Usp2 knockout mice. Please note 'Zeitgeber time 12' means 12 hours after light onset in 12h: light 12h dark housing conditions. It is of importance in the present design because of the strong circadian oscillation of the interest gene. In the Characteristics[genetic m...
ORGANISM(S): Mus musculus 
2013-03-20 | E-MTAB-1442 | biostudies-arrayexpress
ProteomicsThe circadian clock output deubiquitylating enzyme USP2-45 regulates intestinal Ca2+ absorption
In order to identify molecular targets of USP2-45 in the small intestine, we carried out a quantitative proteomics iTraq (Isobaric tag for relative and absolute quantitation) screen to compare proteins from WT and knockout mice. With this analysis we identified, among others, the scaffolding prote...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-22 | PXD000659 | Pride
Intestinal calcium absorption Mass spectrometry Isobaric tagging Circadian clock Ubiquitin-specific protease 2 
GenomicsDeubiquitinase USP2 accelerates endothelial glycocalyx degradation in sepsis-induced ALI by stabilizing MTCH2
Deubiquitinase USP2 accelerates endothelial glycocalyx degradation in sepsis-induced ALI by stabilizing MTCH2
PRJNA1480610 | ENA
GenomicsNext Generation Sequencing Analysis of USP2-AS1_KD A549 cell line
Next Generation Sequencing Analysis of USP2-AS1_KD A549 cell line
PRJNA715397 | ENA
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