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TranscriptomicsThe Relationship between Virus Replication and Host Gene Expression in Lymphatic Tissue during HIV-1 Infection
During HIV-1 infection, there is a massive perturbation of host gene expression, but as yet, genome-wide studies have not identified host genes affecting HIV-1 replication in lymphatic tissue, the primary site of virus-host interactions. In this study, we isolated RNA from the inguinal lymph nodes ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21589 | biostudies-arrayexpress
MetabolomicsGut microbiome influence on metabolic 1 disease in HIV and high-risk populations
Not available
ORGANISM(S): Homo sapiens 
ST001750 | MetabolomicsWorkbench
TranscriptomicsHIV-1 and CA mutant stimulation
Wild type HIV-1 can infect macrophages to establish productive infection without triggering innate immune receptors or type 1 interferon responses that would otherwise restrict virus propagation. We found that HIV-1 capsid mutants that disrupt capsid interactions with two host factors CPSF6 and cycl...
ORGANISM(S): Homo sapiens 
2014-02-12 | E-MTAB-1437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphatic tissue from HIV-1 infected individuals reveals stage-specific, gene-expression signatures in HIV-1 infection
Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS. While each of the three stages has well-known clinical, virologic and immunological characteristics, much less is known of the molecular mechanisms underlying each stage. Here we report lymphatic tissue microarray an...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-16363 | biostudies-arrayexpress
TranscriptomicsComparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1) [miRNA]
Host cells respond to exogenous infectious agents such as viruses, including HIV-1. Studies have evaluated the changes associated with virus infection at the transcriptional and translational levels of the cellular genes involved in specific pathways. While this approach is useful, in our view it pr...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33837 | biostudies-arrayexpress
TranscriptomicsComparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)
This SuperSeries is composed of the following subset Series: GSE33837: Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1) [miRNA] GSE33877: Comparative Expression Profile of miRNA and mRNA in Primary Perip...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33879 | biostudies-arrayexpress
TranscriptomicsMolecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr
Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress
TranscriptomicsCirculating Monocytes in HIV-1 infected Viremic Subjects Exhibit an Anti-Apoptotic Gene Signature
Mechanisms that may allow circulating monocytes to persist as CD4 T cells diminish in HIV-1 infection have not been investigated. We have characterized steady-state gene expression signatures in circulating monocytes from HIV-infected subjects and have identified a stable anti-apoptosis gene signatu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14542 | biostudies-arrayexpress
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
TranscriptomicsTranscription profiling of human primary human macrophages over the course of HIV-1 infection reveals HIV-1 activates macrophages independent of Toll-like receptors
Macrophages provide an interface between innate and adaptive immunity and are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1). Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated ...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-GEOD-13395 | biostudies-arrayexpress
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