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ProteomicsCla4 catalyzed Set1 phosphorylation
H3K4me3 is catalyzed by the Set1/MLL family of methyltransferases, whose function in catalyzing H3K4me3 is unique. Impaired function of Set1/MLL family members can lead to many abnormalities, such as bone and nerve defects, leukemia, and even death. Although the Set1 family plays an important regula...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD042010 | Pride
Cla4 set1 phosphorylation 
ProteomicsSESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing
The glycolytic enzyme, pyruvate kinase Pyk1 maintains telomere heterochromatin by phosphorylating histone H3T11 (H3pT11), which promotes SIR (silent information regulator) complex binding at telomeres and prevents autophagy-mediated Sir2 degradation. However, the exact action mechanism of H3pT11 is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-07 | PXD038138 | Pride
H3k79me3 autophagy h3t11 phosphorylation 
UnknownKun-Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile.
Not available
S-EPMC12359510 | biostudies-literature
UnknownThe association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, red blood cell distribution width, and physical function in elderly non-dialysis patients with chronic kidney disease.
Not available
S-EPMC12318392 | biostudies-literature
MetabolomicsUltrasound Priming Enhances Seed Vigor and Multiple Stresses Tolerance in Aged Maize Seeds
Seed vigor plays a crucial role in germination rate, population uniformity, seedling stress resistance and potential yield at maturity. Here we report a simple, eco-friendly physical method (40-second ultrasound) that rapidly triggers aged seeds to enhance seed vigor and stress resistance. Significa...
2026-07-15 | MTBLS15047 | MetaboLights
Proteomicsyeats cells AP-MS for Jhd2 and Tpk2 relative to article Phosphorylation of Jhd2 by the Ras-cAMP- PKA pathway regulates histone modifications and autophagy
This work uncovers a novel and biologically significant mechanism that directly connects nutrient availability to histone modifications and gene transcription. We report that glycolysis promotes histone H3K4 trimethylation (H3K4me3) by activating Tpk2, a catalytic subunit of protein kinase A (PKA...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-29 | PXD030815 | Pride
Yeast jhd2 
UnknownExploratory study on Th1 epitope-induced protective immunity against Coxiella burnetii infection.
Not available
S-EPMC3907486 | biostudies-literature
UnknownGut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis.
Not available
S-EPMC11423778 | biostudies-literature
Unknownp38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair.
Not available
S-EPMC3561975 | biostudies-literature
UnknownRadiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.
Not available
S-EPMC7846170 | biostudies-literature
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