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MetabolomicsMapping human microbiome drug metabolism by gut bacteria and their genes

Individuals vary widely in their drug responses, which can be dangerous and expensive due to treatment delays and adverse effects. Growing evidence implicates the gut microbiome in this variability, however the molecular mechanisms remain largely unknown. We measured the ability of 76 diverse hum...

2019-07-10 | MTBLS896 | MetaboLights
TranscriptomicsIdentifying genetic determinants needed to establish a human gut symbiont in its habitat
The human gut microbiota is a metabolic organ whose cellular composition is determined by a dynamic process of selection and competition. To identify microbial genes required for establishment of human symbionts in the gut, we developed an approach (insertion-sequencing, or INSeq) based on a mutagen...
ORGANISM(S): Bacteroides thetaiotaomicron 
2009-09-15 | E-GEOD-17712 | biostudies-arrayexpress
TranscriptomicsRNAseq of the human gut commensal Bacteroides thetaiotaomicron wildtype, bt0700 and bt0700 bt3998 (ppGpp0) strains across three conditions: glucose minimal medium, 1h of carbon starvation, and mouse gut colonization
Transcriptional profiles of wildtype and mutant strains bt0700 and bt0700 bt3998 (ppGpp0) of human gut commensal B. thetaiotaomicron were collected to investigate the relevance of the stringent response mediated by the alarmone (p)ppGpp for growth and survival in three different conditions. RNAseq s...
ORGANISM(S): Bacteroides thetaiotaomicron VPI-5482 
2018-07-04 | E-MTAB-6412 | biostudies-arrayexpress
MetabolomicsGNPS - Heterologous expression of clostridithiol genes from Clostridioides difficile in Escherichia coli
Detection of clostridithiols from heterologous expression of one or both putative genes for clostridithiol biosynthesis (originating from Clostridioides difficile wild-type 630) in liquid cultures of E. coli BL21(DE3) grown in modified minimal medium
ORGANISM(S): Escherichia Coli Bl21(de3) (ncbitaxon:469008) 
2025-06-12 | MSV000098169 | GNPS
MetabolomicsGNPS - Chemical characterization of clostridithiol compounds in Clostridioides difficile
Stable isotope labeling of clostridithiol compounds 1-8 in liquid cultures of Clostridioides difficile upon supplementation of polyamines & relevant precursors containing carbon-13/deuterium labels in a modified minimal media. MS/MS of targeted compounds was collected at 30 eV collision energy. Data...
ORGANISM(S): Clostridioides Difficile (ncbitaxon:1496) 
2025-06-12 | MSV000098168 | GNPS
ProteomicsHeterologous expression of clostridithiol genes from Clostridioides difficile in Escherichia coli
Detection of clostridithiols from heterologous expression of one or both putative genes for clostridithiol biosynthesis (originating from Clostridioides difficile wild-type 630) in liquid cultures of E. coli BL21(DE3) grown in modified minimal medium
ORGANISM(S): Escherichia Coli Bl21(de3) (ncbitaxon:469008) 
2025-06-12 | MSV000098169 | MassIVE
ProteomicsChemical characterization of clostridithiol compounds in Clostridioides difficile
Stable isotope labeling of clostridithiol compounds 1-8 in liquid cultures of Clostridioides difficile upon supplementation of polyamines & relevant precursors containing carbon-13/deuterium labels in a modified minimal media. MS/MS of targeted compounds was collected at 30 eV collision energy. Data...
ORGANISM(S): Clostridioides Difficile (ncbitaxon:1496) 
2025-06-12 | MSV000098168 | MassIVE
ProteomicsA human gut bacterium antagonizes neighboring bacteria by altering their protein folding ability
Human gut microorganisms alter the folding capacity of neighboring cells and suggest new strategy for manipulating microbial community dynamics.
ORGANISM(S): Bacteroides Thetaiotaomicron (ncbitaxon:818) 
2024-08-16 | MSV000095628 | MassIVE
GenomicsThe Ovarian Cancer Association Consortium Data Access Committee
Data Access Committee EGAC00001000616
EGAC00001000616 | EGA
GenomicsThe Ovarian Cancer Association Consortium OncoArray genome-wide association study
A custom Illumina genotyping array, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-rela...
EGAS00001002305 | EGA
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