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TranscriptomicsInvestigation of the gene expression profile of LYVE-1-positive macrophages
LYVE-1-positive macrophages were observed to be closely spatially associated with the developing lymphatic vasculature. The role of this population of macrophages in the embryo is uncharacterised. We used microarray analyses to investigate which genes are differentially regulated between LYVE-1-posi...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24492 | biostudies-arrayexpress
TranscriptomicsA defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans
The interaction of Cryptococcus neoformans with phagocytic cells of the innate immune system is a key step in disseminated disease leading to meningoencephalitis in immunocompromised individuals. Transcriptional profiling of cryptococcal cells harvested from cell culture medium or from macrophages ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-08-15 | E-GEOD-41066 | biostudies-arrayexpress
TranscriptomicsMicroarray transcriptomic profiling of patients with sepsis due to faecal peritonitis and pneumonia to identify shared and distinct aspects of the transcriptomic response (validation cohort)
We assayed leukocyte global gene expression for a prospective discovery cohort of 106 adult patients admitted to UK intensive care units with sepsis due to community acquired pneumonia or faecal peritonitis. We assigned all samples to sepsis response signature groups after performing unsupervised an...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-MTAB-5274 | biostudies-arrayexpress
ProteomicsCSF levels of Elongation Factor Tu is associated with increased mortality in human Streptococcus pneumoniae meningitis
Background Mortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae, exceeds 50% in low and middle income countries in sub-Saharan Africa with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host and pathogen proteome in a...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD021268 | Pride
Cerebrospinal fluid Proteomics Hiv Mortality Streptococcus pneumoniae 
MetabolomicsResolving coral photoacclimation dynamics through coupled photophysiological and metabolomic profiling
Corals continuously adjust to short term variation in light availability on shallow reefs. Long-term light alterations can also occur due to natural and anthropogenic stressors, as well as management interventions such as coral transplantation. Although short term photophysiological responses are re...
2019-04-11 | MTBLS768 | MetaboLights
TranscriptomicsMicroarray transcriptomic profiling of patients with sepsis due to faecal peritonitis and pneumonia to identify shared and distinct aspects of the transcriptomic response (discovery cohort)
We assayed leukocyte global gene expression for a prospective validation cohort of 221 adult patients admitted to UK intensive care units with sepsis due to community acquired pneumonia or faecal peritonitis. 10 samples from patients scheduled for elective cardiac surgery were also assayed as non-se...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-MTAB-5273 | biostudies-arrayexpress
UnknownHeterozygous loss of WBP11 function causes multiple congenital defects in humans and mice.
Not available
S-EPMC7823106 | biostudies-literature
TranscriptomicsThe role of HIF in FH-associated renal neoplasia
Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-29988 | biostudies-arrayexpress
GenomicsGenome wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
We have identfied antibodies that support chromatin immunoprecipitation (ChIP) of 11 components of Polycomb repressive complex 1 (PRC1) and shown that multiple variants of PRC1 associate with the same DNA. By performing ChIP-seq with antibodies against CBX6, CBX7, CBX8, RING1 and RING2, in two stra...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-40740 | biostudies-arrayexpress
UnknownManagement of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation.
Not available
S-EPMC12408984 | biostudies-literature
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