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MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
MetabolomicsTranscriptional memory of dFOXO activation in youth curtails later-life mortality
Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mo...
2022-09-28 | MTBLS3251 | MetaboLights
MetabolomicsUnravelling age-driven molecular transitions underlying Pacific Oyster Mortality Syndrome permissiveness in Magallana gigas

Ageing is a progressive and irreversible biological process characterized by the deterioration of physiological functions and increased vulnerability to mortality. Although extensively studied in vertebrates, ageing in long-lived invertebrates remains comparatively unexplored. While ageing typica...

2025-12-08 | MTBLS13463 | MetaboLights
MetabolomicsFood Deprivation Enhances Disease Resistance: Underlying Mechanisms in Oysters Confronted with Pacific Oyster Mortality Syndrome

Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An ad libitum diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (ad libitum vs. starvation...

2025-11-14 | MTBLS13313 | MetaboLights
MetabolomicsStrain level differences in marine microbial parasite-host metabolites and host mortality dynamics

Parasitism is a widespread source of mortality among marine microbial communities, with members of the diverse alveolate group Syndiniales being most prevalent and frequently identified in global omics studies. Despite their ubiquity, not much is known about Syndiniales parasite-host infection dy...

2026-10-05 | MTBLS11219 | MetaboLights
Transcriptomicsmicroarray_summer_mortality_insitu_oyster
Summer mortality of the Pacific oyster Crassostrea gigas is the result of a complex interaction between oysters, their environment and pathogens. Heredity appears to be a major factor determining the sensitivity of oysters to summer mortality, allowing resistant (R) and susceptible (S) lines to be p...
ORGANISM(S): Crassostrea gigas 
2009-08-15 | E-GEOD-16448 | biostudies-arrayexpress
MetabolomicsMetabolomics biomarkers and the risk of overall mortality and ESRD in CKD: results from the Progredir Cohort.
Not available
ORGANISM(S): Homo sapiens 
ST000978 | MetabolomicsWorkbench
TranscriptomicsSuppression of Transcriptional Drift Extends C. elegans Lifespan by Postponing the Onset of Mortality
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we uncover...
ORGANISM(S): Caenorhabditis elegans 
2016-01-06 | E-GEOD-63528 | biostudies-arrayexpress
TranscriptomicsIdentification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study
BACKGROUND: Prediction models for old-age mortality have generally relied upon conventional markers such as plasma-based factors and biophysiological characteristics. However, it is unknown whether the existing markers are able to provide the most relevant information in terms of old-age survival or...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-65218 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis highlights immune response of Pacific oysters as a determinant of resistance to summer mortality
Summer mortality of Crassostrea gigas is the result of a complex interaction between oysters, their environment and pathogens. A large genetic basis and a high heritability were demonstrated for the observed variation in resistance to summer mortality, which offered the possibility to develop lines ...
ORGANISM(S): Crassostrea gigas 
2011-04-22 | E-GEOD-25614 | biostudies-arrayexpress
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