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GenomicsIdentification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
In this work, we characterized the epigenomic integrity of 17 hiPSC lines derived from six different cell types with varied reprogramming efficiencies. We demonstrate that epigenetic aberrations are a general feature of the hiPSC state and are independent of the somatic cell source. Additionally, we...
ORGANISM(S): Homo sapiens 
2012-08-28 | E-GEOD-40372 | biostudies-arrayexpress
GenomicsMethylation orofiling of human stem cell reprogramming by targeted bisulfite sequencing
We report a method for specific capture of an arbitrary subset of genomic targets for single molecule bisulfite sequencing, and for digital quantitation of DNA methylation at a single nucleotide resolution. We used targeted bisulfite sequencing to characterize the changes of DNA methylation during t...
ORGANISM(S): Homo sapiens 
2009-08-28 | E-GEOD-15007 | biostudies-arrayexpress
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